丹参酮ⅡA磺酸钠注射液治疗心脏X综合征的临床观察

Clinical Observation on Cardiac Syndrome X Treated with Sulfotanshinone Sodium Injection

目的观察丹参酮ⅡA磺酸钠注射液治疗心脏X综合征的疗效。方法将60例心脏X综合征患者随机分成两组,常规组予常规治疗,治疗组在常规治疗基础上加用丹参酮ⅡA磺酸钠注射液治疗,治疗15d,观察治疗前后两组典型心绞痛发作频率、心电图运动试验缺血型ST段压低幅度及C反应蛋白(CRP)的变化。另选本院同期健康体检者20名作为正常组。结果心脏X综合征患者血CRP较正常人增加(P<0.01)。治疗组与常规组治疗后与治疗前相比心绞痛发作频率显著减少(P<0.05),心电图运动试验缺血型ST段压低幅度显著改善(P<0.05),血CRP浓度显著下降(P<0.05),但治疗组改善程度优于常规组(P<0.05)。结论常规治疗基础上加用丹参酮ⅡA磺酸钠注射液可以有效治疗心脏X综合征,丹参酮ⅡA磺酸钠注射液可以降低心脏X综合征患者血CRP水平可能是其有效的作用机制之一。

Objective To investigate the effect of sulfotanshinone sodium injection on cardiac syndrome X. Methods Sixty patients with cardiac X syndrome were randomly divided into 2 groups： Routine therapy group （n= 30） treated with regular treatment, and treatment group （n： 30） treated with regular treatments and sulfotanshinone sodium injection. All patients were treated for 15 days. And the frequency of typical angina occurrence,the latitudes of ST segment depression in treadmill test,and the alteration of blood C-response protein were recorded. Twenty healthy people were selected as a control group. Results Compared with the control group, the concentration of blood C- response protein in the patients with cardiac syrldr9me X were obviously increased （P〈0.01）. After treatment, the frequency of typical angina occurrence and the concentration of blood C - response protein in both groups were significantly decreased（P〈0.05） ,and the result of treadmill test was also improved （P〈0.05）. Compared with the routine therapy group, the frequency of typical angina occurrence and the concentration of blood C - response protein in the treatment group were sig- nificantly decreased（P〈0.05） ,and the result of treadmill test was also improved（P〈0.05）. Conclusion Sulfotanshinone sodium in- jection was effective to treat patients with cardiac syndrome X. Sulfotanshinone sodium injection could decrease the concentration of blood C- response protein in patients with cardiac syndrome X.