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绵阳市老年冠心病与血浆同型半胱氨酸的相关性观察 被引量：4

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摘要 目的研究绵阳市老年冠心病与血浆同型半胱氨酸(Hcy)的相关性。方法对412例可疑冠心病的老年患者行冠脉造影,分为冠心病组和冠脉造影正常的对照组,冠心病组分为稳定型心绞痛(SAP)组和急性冠脉综合征(ACS)组。以Gensini积分评价冠状动脉病变程度,测定血浆Hcy、血糖、血清肌酐(Cr)、胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、血清叶酸、维生素B12和维生素B6水平。分析血浆Hcy与年龄、Gensini积分、血糖、Cr、TC、TG、HDL-C、LDL-C、血清叶酸、维生素B12和维生素B6水平的关系。结果血浆Hcy随年龄的增长而显著升高;与对照组相比,SAP组和ACS组Hcy水平均升高显著,且ACS组较SAP组升高明显(P<0.01),血浆Hcy随着Gensini积分的增加而升高(P<0.05);血浆Hcy致冠心病的优势比(OR)为2.324,其95%的可信限1.665～4.871。结论血浆Hcy是导致绵阳市老年冠心病的独立危险因素。
作者 王羽
机构地区 四川绵阳中心医院心脏中心
出处 《中西医结合心脑血管病杂志》 2013年第8期940-941,共2页 Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
基金 四川省医学会基金课题(No.SHD11-11)
关键词 冠心病 绵阳市 老年人 同型半胱氨酸
分类号 R541.4 [医药卫生—心血管疾病] R256.2 [医药卫生—中医内科学]
  • 相关文献

参考文献11

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共引文献23

同被引文献32

  • 1陈黔妹,沈扬,樊东升.颈动脉粥样硬化与进展性卒中的相关因素研究[J].中国康复理论与实践,2004,10(12):731-732. 被引量：48
  • 2李刚,周兴文.新的冠心病危险因素[J].心血管病学进展,2005,26(3):266-271. 被引量：24
  • 3Li Z, Sun L, Zhang H, et al. Elevated plasma homocysteine was associated withhemorrhagic and ischemic stroke, but methylenetetrahydrofolate reductase gene C677Tpolymorphism was a risk factor for thrombotic stroke: a Multicenter Case-Control Study inChina[J].Stroke 2003;34(9):2085-90.
  • 4Wald DS, Law M, Morris JK. Homocysteine and cardiovascular disease: evidenceon causality from a meta-analysis[J].Br Med J 2002;325(7574):1202-6.
  • 5Gensini GG.A more meaningful scoring system for determining the severity ofCoronary heart disease. Am J Cardiol,1983,51:606.
  • 6Stampfer MJ, Malinow MR, Willettwc WC, et al. A prospective study of plasmahomocysteine and risk of myocardial infarction in US physicians[J].JAMA, 1992 ,268(7):877-881.
  • 7Priyanka S,Senthilkumar RD.Mining literature for a comprehensive pathwayanalysis:A case study for retrieval of homocysteine related genes for genetic and epigeneticstudies[J].Lipids Health Dis,2006,5(1):1.
  • 8Geisel J,Hennen B,Hubner U, et al.The impact of hyperhomocysteinemia as acardiovascular risk factor in the prediction of coronary heart disease[J].Clin Chem Lab Med,2003,41(11):1513-1517.
  • 9Beltowski J.Protein homocysteinylation:a new mechanism ofathergenesis[J].Postepy Hig Med Dosw(online),2005,59(3):392-404.
  • 10Sacco RL, Adams R, Albers G, et al. Guidelines for prevention of stroke inparients with ischemic stroke or transient ischemic attack [J]. Circulation, 2006,113(10):e409-e449.

引证文献4

二级引证文献5

中西医结合心脑血管病杂志
2013年 第8期

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