慢性砷中毒患者尿砷含量与皮肤改变的相关性研究

Relationship between urinary arsenic content and skin changes in patients with arsenism

目的探讨慢性砷中毒皮肤改变与尿砷含量的关系。方法收集80例慢性砷中毒患者的临床资料,分析皮肤损害的临床特征及变化规律。结果临床皮肤改变以角化人数最多(93.75%),脱色次之(88.75%),色素沉着最少(57.5%);皮肤角化、角化+脱色及角化+脱色+色素沉着三组的尿砷含量差异有统计学意义(P<0.001)。相关性分析显示尿砷含量与患者皮肤损害之间存在着正相关关系(r s=0.573,P<0.05)。结论慢性砷中毒皮肤改变从角化开始,然后是角化加重或脱色加重,最后是色素沉着加重。随尿砷含量逐渐升高,皮损逐渐加重。

Objective To investigate the relationship between urinary arsenic content and skin changes in patients with arse- nism. Methods Totally,80 patients with arsenism were enrolled in this research. The clinical feature and variation of their skin lesion were analyzed. Results The most common skin changes observed are keratinization （ 93.75 % ） , depigmentation （ 88.75 % ） and hyper- pigmentation（ 57. 5% ） ,respectively. Significant differences were observed in the urinary arsenic content of patients with only skin kera- tinization,keratinizatiort/depigmentation and keratinization/depigmentation/hyperpigmentation （P 〈 0. 001 ）. Statistical analysis re- vealed positive correlation between urinary arsenic content and skin changes （rs = 0. 573, P 〈 0. 05 ）. Condusions The skin changes of patients with arsenism usually initiate from skin keratinization, then depigmentation, and hyperpigmentation finally. With the increase of urinary arsenic content, the skin lesion aggravate accordingly.