剖宫产同时行子宫肌瘤剔除术中应用卡前列素氨丁三醇的效果及安全性观察

Efficiency and safety of application of hemabate in myomectomy at time of cesarean delivery

目的探讨卡前列素氨丁三醇注射液在剖宫产同时行子宫肌瘤剔除术中的疗效及安全性。方法将120例剖宫产同时行子宫肌瘤剔除术的患者分为卡前列素氨丁三醇组(50例)及缩宫素组(70例),比较两组术中出血、手术时间、住院天数、血红蛋白(Hb)下降、恶露持续时间、不良反应发生率方面的差异。结果卡前列素氨丁三醇组术中出血、Hb下降、手术时间和恶露持续时间明显少于缩宫素组,差异有统计学意义(P<0.05),不良反应发生率高于缩宫素组(P<0.05),但程度一般较轻,不需特殊处理。两组住院时间差异无统计学意义(P>0.05)。结论剖宫产同时行子宫肌瘤剔除术应用卡前列素氨丁三醇术中出血少,安全可靠,效果满意。

Objective To observe the efficiency and safety of application of hemabate in myomectomy at time of cesarean de- livery. Methods One hundred and twenty patients undergone myomectomy at time of cesarean delivery from January 2009 to June 2012 were divided into hemabate group （ n = 50 ） and oxytocin group （ n = 70 cases ）. The intra- operative bleeding, operation time, hospitaliza- tion days, hemoglobin（ Hb）, duration of lochia and incidence of adverse reaction were compared between the two groups. Results The intra-operative bleeding, decreased hemoglobin （Hb）, surgery time and duration of lochia in the hemabate group were significantly lower than that in the oxytocin group（ all P 〈 0. 05）. However, adverse reaction rate in the hemabate group was significantly higher than that in the oxytocin group （P 〈 0. 05 ） although it was lighter without special treatment. No significant different in the hospitalization time was found between the two groups. Conclusions It may conclude that repeated application of hemabate in myomectomy at time of cesarean delivery has advantages of less bleeding, safe and reliable.