摘要
感音神经性聋是一种常见的致残性疾病,药物治疗仍然是重要手段,全身给药是目前主要的给药方式。然而,由于血-迷路屏障的存在,全身给药方式给予的药物在耳蜗中分布的浓度较低,一些药物甚至不能通过血-迷路屏障,因此,常规全身给药方式治疗感音神经性聋的效果欠佳。而内耳局部注射的方式可有效绕过血-迷路屏障,可望克服全身给药耳蜗中药物浓度分布过低的缺陷;同时,随着基因工程技术和细胞学技术的飞速发展,耳蜗局部基因转染及耳蜗干细胞植入技术也被运用到感音神经性聋防治的研究中。本文将就内耳局部药物注射、局部基因转染及干细胞植入防治感音神经性聋的现状及展望进行综述。
Sensorineural hearing loss is a common disabling disease. The main therapy against this disease in the pres- ent age is that medication is administered via systemic application. However, due to the blood - labyrinth barrier, the concen- tration of drug performs low level when it is administered through systemic application, which causes low therapeutic effect against sensorineural hearing loss. This defect could be averted to large extent via local application, through which the blood-labyrinth barrier is bypassed. In the meantime, along with the developments the technologies of genetic engineering and cytology, local gene transfection and stem cell implantation are applied in the researches of treatments for sensorineural hear- ing loss. This review will examine the mechanism and the potential of therapeutics against sensorineural hearing loss via local application in cochlea.
出处
《中华耳科学杂志》
CSCD
北大核心
2013年第3期401-407,共7页
Chinese Journal of Otology
关键词
感音神经性聋
耳蜗
听功能
基因转染
干细胞植入
Sensorineural hearing loss
cochlea
hearing function
gene transfection
stem cell implantation
