冠心病患者血清vasostatin-2水平降低与冠状动脉病变严重程度相关

Correlation between decrease in vasostatin-2 level and severity of coronary heart disease

目的:探讨嗜铬粒蛋白A(CgA)降解片段vasostatin-2(VS-2)与冠心病发生的关系。方法:入选冠状动脉(冠脉)造影证实的冠心病(冠脉腔内径狭窄≥50%)患者554例和对照281例(冠脉造影阴性或冠脉腔内径狭窄<30%)。采用酶联免疫吸附(ELISA)法检测2组患者血清VS-2、高敏C反应蛋白(hs-CRP)、可溶性细胞间黏附分子1(sICAM-1)及可溶性血管细胞黏附分子1(sVCAM-1)水平。运用多元Logistic回归分析冠心病的危险因素。结果:与对照组相比,冠心病患者血清VS-2水平显著降低[(4.45±2.64)μg/L比(5.82±3.22)μg/L,P<0.001],hs-CRP、sICAM-1及sVCAM-1水平升高(均P<0.001)。VS-2水平与冠心病病变支数负相关(r=-0.206,P<0.05)。多元Logistic回归分析显示VS-2水平下降是冠心病的危险因素(P<0.05)。结论:冠心病患者血清VS-2水平显著下降,与冠心病严重程度呈负相关。

Objective To investigate the correlation between vasostatin-2 （VS-2）, a peptide fragment derived from chromogranin A, and severity of coronary heart disease （CHD）. Methods Five hundred and fifty four patients with CHD （luminal diameter narrowing i〉50% ） were enrolled in this study, and 281 subjects with normal coronary arteries or non- significant CHD （luminal diameter narrowing 〈30%） were served as controls. Enzyme-linked immunosorbent assay （ELISA） was performed to determine serum levels of VS-2, high-sensitivity C-reactive protein （hs-CRP）, soluble intercellular adhesion molecule 1 （sIC_AM-I） and soluble vascular cell adhesion molecule 1 （sVCAM-1）. Results Compared with control group, serum VS-2 level was significantly lower in CHD patients [（4.45±2.64） μg/L vs （5.82±3.22） μg/L, P〈0.001], hs- CRP, sICAM-1 and sVCAM-1 level was significantly higher in CHD patients （all P〈0.001）. VS-2 was negatively correlated with number of diseased coronary arteries （r=-0.206, P〈0.05）. Muhivariable logistic regression analysis demonstrated that decreased vasostatin-2 level is an independent risk factor for CHD （P〈0.05）. Conclusions Serum VS-2 level is significantly lower in CHD patients and is correlated negatively with the severity of CHD.