抗炎--艾灸温通的效应机制

Anti-inflammatory:effect mechanism of warming-dredging in moxibustion

从艾灸适应病谱和古代文献记载分析艾灸抗炎的普遍性;从艾灸治疗炎性疾病的系列研究、热证可(贵)灸的科学内涵指出艾灸抗炎的特异性;从艾灸对慢性炎性反应的4个基本通路均可以产生影响的系列研究结果说明艾灸抗炎的整体性;从对炎性反应的过度与不足均具有调整作用说明艾灸抗炎的双向性,论证艾灸温通效应机制主要在于其抗炎作用。最后提出灸法抗炎与温热觉感受TRPV(瞬时受体电位香草酸亚家族)通道蛋白相关的可能性机制。艾灸温通效应机制在于抗炎,而艾灸抗炎机制的明确将为艾灸防治重大疾病提供理论基础。

The universality of anti-inflammation in moxibustion is analyzed in this article from its adaptation disease and ancient documentary records. The specificity of anti-inflammation in moxibustion is pointed out from its disease series research and scientific fact that moxibustion could be used for heat syndrome. The integrity of an- ti-inflammation in moxibustion is explained by series research result that four basic circulations of moxihustion for chronic inflammation are all effective. The two-way characteristic of moxibustion anti-inflammation is explained from the fact that moxibustion has regulation function both for excess and insufficiency of inflammation to demon- strate the effect mechanism of warming-dredging in moxibustion lies in its anti-inflammation. At last, the relevant possible mechanism between moxibustion anti-inflammation and transient receptor potential vanilloid （TRPV） is proposed. The effect mechanism of warming-dredging in moxibustion lies in anti-inflammation, which could pro- vide theoretic basis for prevention and treatment of moxibustion for serious diseases.