2002-2011年北京地坛医院急性肝炎住院患者病因研究

Study on the etiology of acute hepatitis hospitalized patients in Beijing Ditan Hospital from 2002 to 2011

目的探讨2002--2011年北京地坛医院收治的急性肝炎住院患者的病因。方法统计2002--2011年地坛医院所收治的急性肝炎患者，总结急性肝炎病因变化的特点，并初步分析形成原因。结果2002--2011年北京地坛医院收治急性肝炎6235名，年龄12—78岁。男性4309人，女性1926人。急性肝炎中，急性病毒性肝炎占70．44％-85．07％，CMV、EBV、药物性肝损害〈5％，急性丁型及急性丙型肝炎〈1．10％。2002--2011年北京地坛医院急性肝炎发病人数及构成发生明显变化。急性肝炎占总住院患者的比例由20．38％降至2．05％，比10年前低10倍。10年间急性甲型肝炎病毒发病人数递减趋势最明显，下降99．1l％，急性乙型肝炎发病人数下降45．07％，急性戊型肝炎发病人数下降62．28％。急性肝炎构成比也在发生明显变化。急性甲型肝炎比例由2002年的31．31％，降至2011年1％以下，比10年前约低30倍。急性乙型肝炎比例由2002年26．47％上升至2011年45．88％，10年间上升约2倍。急性戊型肝炎由2002年26．73％，上升至32．05％，10年间上升1．20倍左右。结论2002--2011年北京地坛医院收治急性肝炎占总住院患者比例由20．38％降至2．05％。急性肝炎的构成比发生变化。

Objective To explore the etiology of acute hepatitis hospitalized patients in Beijing Ditan Hospital from 2002 to 2011. Methods We summed up the changes in the characteristics of the etiology of acute hepatitis of patients mentioned above, and preliminarily analyze the causes. Results From 2002 to 2011, 6235 patients with acute hepatitis were admitted to Ditan Hospital, aged between 12 and 78 years old, Of which 4309 were male and 1926 female. Acute viral hepatitis accounted for 70.44% -85.07% , while CMV, EBV, drug-induced liver injury accounted less than 5% , and acute hepatitis D and acute hepatitis C less than 1.10%. From year to year, the incidence and constitution of acute hepatitis changed significantly. The proportion of patients with acute hepatitis in total hospitalized patients was from 20. 38% to 2.05%. In 10 years, the percentage of acute hepatitis A decreased most obviously, about 99. 11% , while 45.07% decline in incidence of acute hepatitis B and 62. 28% of acute hepatitis E. The constituent ratio of acute hepatitis also changed significantly. The proportion of acute hepatitis A declined from 31.31% in 2002, to less than 1% in 2011. The proportion of acute hepatitis B increased from 26.47% in 2002 to 45.88% in 2011, an increase of about 2 folds in 10 years. The proportion of acute hepatitis E increased from 26. 73% in 2002 to 32. 05% in 2010, a rise of 1.20 times in 10 years. Conclusions The proportion of patients with acute hepatitis in total hospitalized patients decreased from 20. 38% in 2002 to 2.05% in 2011 in Beijing Ditan Hospital. The constituent ratio of acute hepatitis changed, too.