表现为慢性反复发作性皮肤水疱的变应性肉芽肿病1例

A Case of Allergic Granulomatosis Presented with Chronic Recurrent Cutaneous Vesicles

患者女,52岁,反复双下肢皮疹伴麻木感9个月,发热1周,外周血嗜酸性粒细胞增高9个月,既往有过敏性哮喘3年。皮肤科情况:双下肢肿胀性红斑,上有融合性水疱,疱液浑浊。血WBC 12.16×109/L,嗜酸细胞百分比67.9%;神经电图检查提示双下肢神经源性损害。组织病理示:真皮血管周围大量嗜酸性粒细胞浸润。诊断为变应性肉芽肿病。予泼尼松50mg,1次/d,口服联合环磷酰胺400mg,2周1次,治疗有效,目前仍在随访中。

A case of allergic gramdomatosis （ Churg-Strauss Syndrome） was reported. A 52-year-old woman presented with recurrent rash and numbness on both lower extremities for 9 months and got fever for 1 week. Her blood routine exams showed increased eosinophilic granulocytes in the past 9 months. She complained of asthma for 3 years. Physical examination revealed swollen erythemas on both lower limbs with fusion blisters which conrained turbid fluid in it. The absolute white cell count came out to be 12.16×10^9/L with the EO% 67.9% ;Nerve EMG suggested neurogenic damage of lower limbs. Histopalhological examination showed an infiltration of large amounts of eosinophils surrounding the vessels in the dermis. Diagnosis of Allergic granulomatosis （Churg-Stauss syndrome） was made finally. The patient was given oral prescliption of prednisone 50mg qd and cycylophosphamide（ CTX ）400mg intravenously once a week. The patient was still under follow-up.