间充质干细胞治疗眼免疫性疾病的新进展

Research advances on mesenchymal stem cells therapy for ophthalmologic immunological diseases

骨髓间充质干细胞(mesenchymal stem cell,MSC)是指存在于骨髓基质细胞的非造血细胞来源的细胞亚群,它们不仅具有多潜能分化作用,同时还有免疫调节作用。目前,MSC在免疫调节方面的作用越来越受到国内外学者的关注。本文就MSC、实验性自身免疫性葡萄膜炎和MSC对实验性自身免疫性葡萄膜炎治疗的基础及应用方面的研究做了系统的综述。

Mesenchymal stem cells（MSC） are a cell subset derived from non-hem- atopoietic cells in bone marrow stroma, which are capable of multi-potential differentia- tion and immunoregulation. MSC are becoming increasingly attention-focused in aca- demic fields around the world. This article systematically reviews fundamental and clini- cal studies on MSC, experimental autoimmune uveitis and MSC therapy for experimental autoimmune uveitis.