青春期和育龄期多囊卵巢综合征的临床生化特征分析比较

Clinical features of polycystic ovary syndrome among adolescents and adults

目的:探讨青春期多囊卵巢综合征(PCOS)患者的临床生化特征。方法:收集2010年8月至2012年10月四川大学华西二院妇产科门诊收治的126例青春期PCOS患者(青春期组)和368例育龄期PCOS患者(育龄期组),分析和比较两组患者的临床及生化指标。结果:(1)青春期组患者的初潮年龄(12.59±1.39)显著低于育龄期组(13.28±5.36)(P<0.05),但均在正常范围内;高雄症状的程度和发生率均显著高于育龄期组(P<0.05),体重指数(BMI)、腰围、腰臀比(WHR)和平均舒张压均显著低于育龄期组(P<0.05);(2)两组的平均血睾酮(T)、LH、FSH、LH/FSH及FINS、HOMA-IR、HDL无显著差异(P>0.05)。青春期组的平均空腹血糖(FPG)、胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL)、TC/HDL及LDL/HDL均显著低于育龄期组(P<0.05);(3)青春期组的腰围≥80cm、收缩压≥130mmHg和FPG≥5.6mmol/L的发生率显著低于育龄期组(P<0.05)。结论:青春期PCOS患者具有PCOS特征性的高雄、代谢障碍问题,需加以关注,并及早治疗。

Objective：To explore the clinical and biochemical features of adolescents with polycystic ovary syndrome（PCOS）.Methods：A retrospective analysis on adolescent and adult PCOS patients from Aug.2010 to Oct.2012 was conducted.Results：（1）The age at menarche,duration and age of oligomenorrhea,body mass index（BMI）,waist circumference,waist-to-hip ratio（WHR） and blood pressure were significantly lower in adolescent PCOS when compared with the adult patients（P＆lt;0.05）.The Ferriman-Gallwey（F-G） score and acne score in adolescent PCOS were significantly higher than those of adult PCOS（P＆lt;0.05）.（2）The fasting plasma glucose（FPG）,total cholesterol（TC）,triglyceride（TG）,and low density lipoprotein（LDL） were significantly lower in adolescent PCOS.However,T,the fasting insulin（FINS） and homeostasis model assessment-insulin resistance index（HOMA-IR） showed no difference between them.（3）The index of metabolic disturbance in adolescent PCOS had lower prevalence.Conclusions：Adolescent PCOS have typically hyperandrogenism and metabolic disturbance,which need to be care and in timely treatment.