芍药化学成分和药理作用研究进展

Advances in studies on chemical constituents and pharmacological effects of Paeonia lactiflora Pall.

芍药是一种用于治疗多种疾病的传统中药。芍药除含有芍药苷和苯甲酰芍药苷等成分外,还包含异芍药苷和4-氧-甲基-芍药苷等多种新的化学成分。芍药具有抗炎、镇痛、抗菌、抗氧化、抗癌、抗抑郁和抗肝纤维化等作用;对自身免疫性疾病、心脑血管疾病和神经退行性疾病也能起到改善和治疗作用。上述研究进一步明确了芍药的药理作用机制,为其临床应用提供了理论依据,更有助于西方国家对中药的认可。本文综述了近年来国内外有关芍药化学成分和药理作用的研究进展。

It is generally known that P.lactiflora is a traditional Chinese materia medica（TCMM）,which has been used in the treatment of an array of diseases.In recent years,many papers have been published describing the new chemical constituents and pharmacological effects of P.lactiflora.Besides many proverbial chemical constituents,such as paeonifiorin and benzoylpaeoniflorin,there are many new chemical constituents found from the root,flower,leaf and fruit of P.lactiflora,such as isopaeoniflorin and 4-O-methyl-paeoniflorin.Meanwhile,P.lactiflora has a number of pharmacological activities,including anti-inflammatory,analgesic,antibacterial,antioxidant,anticancer,antidepressant and anti-liver fibrosis effects.P.lactiflora can also treat autoimmune diseases,cardiovascular and cerebrovascular diseases as well as neurodegenerative diseases.All these findings related to pharmacological effects and mechanisms of P.lactiflora not only provide an experimental support and theoretical basis for clinical application,but also help make TCMM better-known to the world.