p27Val109Gly基因多态性与肿瘤易感性的Meta分析

p27Val109Gly polymorphism and cancer risk:a systematic review and Meta-analysis

目的:通过Meta分析系统评价p27Val109Gly基因多态性与肿瘤易感性的关系。方法:检索PubMed、Medline、Web of Science和中国知网等数据库中研究p27Val109Gly基因多态性与肿瘤易感性关系的研究。运用Rev-Man5.0软件进行异质性检验、系统性评价和分层亚组分析,计算合并OR及95%CI;应用State 11.0软件进行定量发表偏倚检验。结果:共纳入13项研究,累计病例组4 894例,对照组5 413例。G等位基因携带者肿瘤总体易感性降低,OR=0.81,95%CI=0.66～0.99,P=0.04,尤其是前列腺癌(OR=0.60,95%CI=0.36～0.98,P=0.04)和食管癌(OR=0.34,95%CI=0.22～0.55,P<0.01)。剔除不符合或不能进行HWE检验的研究后,再次行Meta分析。结果显示,G等位基因与肿瘤易感性无相关性,OR=0.82,95%CI=0.64～1.03,P=0.09。高加索人群(OR=0.97,95%CI=0.84～1.12,P=0.67)和亚洲人群(OR=0.77,95%CI=0.57～1.02,P=0.07)、基于医院(OR=0.70,95%CI=0.42～1.17,P=0.17)和社区(OR=0.86,95%CI=0.67～1.11,P=0.24)的肿瘤患者,p27Val109Gly基因多态性与肿瘤易感性无明显相关性。结论:p27Val109Gly基因多态性G等位基因与肿瘤的易感性呈负相关,尤其是前列腺癌和食管癌。这种相关性在高加索人、亚洲人及对照组来源于医院或社区的患者中不显著。

OBJECTIVE： To investigate the association between p27Val109Gly polymorphism and cancer susceptibility. METHODS：We searched relevant articles from Pub med, Medline,Web of Science,CNKI database. We made systematicall and stratified evaluation by statistical analysis software RewMan5.0. We tested publication bias by State 11.0. RESULTS： Thirteen studies involving 4 894 cases and 5 413 controls were included. Total analysis found that G-allele could decrease susceptibility of all tumor （OR= 0.81,95% CI= 0.66 - 0.99, P = 0.04）, specially prostate cancer （OR = 0.60, 95%CI=0. 36-0.98,P=0.04） and esophagus cancer （OR=0. 34,95%CI=0.22-0. 55,P〈0. 01）. Re-analysis showed that there was no association（OR= 0.82,95% CI= 0. 64-1. 03 , P = 0.09） between the p27Val109Gly polymorphism and cancer risks. There was no association between Caucasian （OR=0.97,95%CI=0.84-1.12 ,P=0.67） and Asian （OR= 0.77,95%CI=0.57-1.02,P=0.07） in hospital-based （OR=0.70,95%CI=0.42-1.17,P=0.17） and populationbased （OR= 0.86,95% CI= 0.67-1.11 ,P=0.24） patients. CONCLUSION：G-allele of p27Val109Gly polymorphism may be related with the cancer risk,especially prostate cancer and esophageal cancer as a low-risk factor. This relevance is not notable in Caucasians, Asians and patients from hospital. [