MK-801对脊髓缺血再灌注损伤的保护作用被引量：1

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摘要脊髓缺血再灌注损伤（Ischemia—reperfusion inju—ry，IRI）是主动脉手术中最危险的并发症之一。手术时，夹闭主动脉会引起脊髓血供中断，导致不可逆的神经细胞损伤，甚至引起术后截瘫和偏瘫¨引。近年有报道称MK-801在脊髓IRI中能够起到神经保护作用。

作者刘怀普李嘉欣庄建朱平

机构地区广东省心血管病研究所心外科广东省人民医院心外科广东省医学科学院

出处《中华胸心血管外科杂志》 CSCD 北大核心 2013年第8期499-501,共3页 Chinese Journal of Thoracic and Cardiovascular Surgery

基金中国科技部国际合作项目（2008DFA31140、2010DFA32660）中国科技支撑计划项目（2011BAI11B22）

关键词脊髓缺血再灌注损伤 MK-801 神经保护作用神经细胞损伤术后截瘫手术中主动脉并发症

分类号 R363 [医药卫生—病理学]

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参考文献29

1Papakostas JC, Matsagas MI, Toumpoulis IK, et al. Evolution of spinal cord injury in a porcine model of prolonged aortic occlusion. J Surg Res ,2006,133 : 159-166.
2Kawaharada N, Morishita K, Hyodoh H, et al. Magnetic resonance angiographie localization of the artery of Adamkiewicz for spinal cord blood supply. Ann Thorac Surg,2004,78:846-852.
3Alilain WJ, Goshgarian HG. MK-801 upregulates NR2A protein lev- els and induces functional recovery of the ipsilateral hemidiaphragm following acute C2 hemisection in adult rats. J Spinal Cord Med, 2007,30:346-354.
4Vornov JJ. Toxic NMDA-receptor activation occurs during recovery in a tissue culture model of ischemia. J Neurochem, 1995,65: 1681- 1691.
5Tseng EE, Brock MV, Kwon CC, et al. Increased intracerebral excitatory amino acids and nitric oxide after hypothermic circulatory arrest. Ann Tborae Surg, 1999,67:371-376.
6姚晓光,张为,陈百成,申勇,董玉昌.6-羟基多巴胺和MK-801抑制脊髓水肿的效应(英文)[J].中国组织工程研究与临床康复,2007,11(12):2382-2384. 被引量：1
7Kocaeli H, Korfali E, Ozturk H, et al. MK-801 improves neurological and histological outcomes after spinal cord ischemia induced by transient aortic cross-clipping in rats. Surg Neurol,2005,64 Suppl 2 : S22 -S27.
8李仁斌,陈文昌,徐杰,等.MK-801在脊髓缺血再灌注损伤中的作用.福建医科大学报,2004,38:390-391.
9张忱,张文,徐亚萍,李刚,程兰英.应用NMDA受体拮抗剂MK-801治疗局灶性脑缺血的实验研究[J].中日友好医院学报,2002,16(5):293-297. 被引量：4
10Sundstrom E, Mo LL. Polyamine and redox modulation of [3H] MK-801 binding to N-methyl-D-aspartate receptors in the spinal cord and cerebral cortex. Pharrnacol Toxicol,2001,88 :342-348.

二级参考文献21

1Belhage B, Frandsen A, Schoosboe A. Temporal and spatial differences in intracellular Ca2 + changes elicited by glutamate in single cultured neocortical neurons[J]. Neurochem, 1996,29(3) :247-253.
2Sieosjo BK, Bengtsson F. Calcium fluxes, calcium antagonists and calcium-related pathology in brain ischemia, hypoglycemia and spreading depression: A unifying hypothesis [J]. J Cereb Blood Flow Metab, 1989,9 (2): 127-140.
3Park L. Efficacy of a competitive NMDA antagonist in focal cerebral ischemia in the rat[J]. Neuro Sci Lett, 1992,147 (1):41-44.
4Riyssel DW. Effect of MK-801 on focal brain infarction in rats [J]. J Hypertension, 1992,19 (1) :40-46.
5Wallace MC, Teasdale GM, McCulloch J. Autoradiographic analysis of 3H-MK-801 in vivo uptake and in vitro binding after focal cerebral ischemia in the rat [J]. J Neurosurg, 1992,76(1) :127-133.
6McCulloch F. Glutamate receptor antagonists in experimental focal cerebral ischemia [J]. Acta Neurochir Suppl Wien,1993,57:73-79.
7Nathal D. NMDA receptor antagonists in focal cerebral ischemia: an expermental model [J]. Gac Med Mex, 1993,129 (2):125-130.
8Schulz H. Improved therapeutic window for treatment of histo toxic with a free radical spin trap [J]. J Cereb Blood FlowMetab, 1995,15(6) :948-952.
9Siesjo BK, Memezawa H, Smith ML. Neurocytoxicity: pharmacological implications[J]. Fundam Clin Pharmacol,1991,5(9) :755-767.
10Gill R, AndineP, Hillered L, etal. The effect of MK-801 on cortical spreading depression in the penumbral zone following focal ischemia in the rat [J]. J Cereb Blood Flow Metab,1992,12(3) :371-379.