口服戊酸雌二醇对自然更年期大鼠超敏C反应蛋白的影响

Effect of oral estradiol valerate on the high sensitivity C-reactive protein in climacteric SD rats

目的探讨口服戊酸雌二醇对自然更年期雌性SD大鼠超敏C反应蛋白(high sensitivity C-reactive protein,hs-CRP)及白介素-6(interleukin-6,IL-6)水平的影响。方法将70只15月龄雌性SD大鼠采用数字表法随机分为实验组和对照组,实验组进行戊酸雌二醇灌胃给药,对照组给予等量0.9%氯化钠注射液,14周腹主动脉采血,测定血清超敏C反应蛋白与白介素-6水平。结果实验组血清hs-CRP水平明显低于对照组(P<0.05),实验组血清IL-6水平较对照组有降低趋势,但差异无统计学意义(P>0.05)。结论口服戊酸雌二醇可以降低血清hs-CRP的水平,对心血管疾病起到一个积极的保护作用。

Objective To investigate the effects of estrogen on the high sensitivity C-reactive protein （hs-CRP）, IL-6. Methods Seventy SPF female SD rats, fifteen-month-old, were randomly divided into two groups by digital table method： treatment group and control group. The treatment group was given estradiol valerate orally, once per day, the control group was orally fed with physiological saline intragastric administration, once per day, fourteen weeks. After the treatment, blood samples were taken from the rats to assess the level of hs-CRP, IL-6. Results Fourteen weeks after intragastric administration, in the treatment group, serum hs-CRP level was lower than that in the control group（P〈0.05） ; while the IL-6 level was lower than that in control group（P〉O. 05）. Conclusion Intragastric administration of estradiol valerate might decrease the hs-CRP, so estradiol may play a positive protective role in cardiovascular disease prevention.