原发性高血压患者血和尿中性粒细胞明胶酶相关脂质运载蛋白的改变及临床意义

Changes of neutrophil gelatinase-associated lipocalin in patients with primary hypertension and its clinical significance

目的检测原发性高血压患者血清和尿液中性粒细胞明胶酶相关脂质运载蛋白(neutrophil gelatinase-associated lipocalin,NGAL)浓度,探讨其临床意义。方法 117例原发性高血压患者和110例健康体检者作为研究对象,酶联免疫吸附方法检测血NGAL和尿NGAL浓度,同时测血肌酐及尿β2微球蛋白(β2-microglobulin,β2-mG),两组间进行比较。结果高血压组患者血NGAL浓度(1.88±1.49)μg/L、尿NGAL浓度(1.19±0.64)μg/L,对照组血NGAL浓度(0.78±1.01)μg/L、尿NGAL浓度(0.58±0.32)μg/L。高血压患者血NGAL、尿NGAL浓度均高于对照组(P<0.05)。两组间血肌酐比较差异无统计学意义(P>0.05)。高血压患者尿β2-mG较对照组升高,差异有统计学意义(P<0.05)。结论原发性高血压患者血清及尿NGAL浓度升高,这对于早期发现、早期防治高血压性肾损害有重要的临床意义。

Objective To investigate the changes of serum and urine neutrophil gelatinase-associated lipocalin （NGAL） in patients with primary hypertension and its clinical significance. Methods A total of 117 patients with primary hypertension and 110 healthy persons were studied. We detected serum and urine NGAL protein levels with enzyme linked irnmunosorbent assay （ ELISA）, serum creatinine（Scr） and urine β2-mG. Results The concentration of serum NGAL in hypertensive patients were（ 1.88± 1.49 ） μg/L, urine NGAL were（1.19±0.64） μg/L, the serum NGAL of control group were（0.78±1.01 ） p,g/L, urine NGAL were（0.58±0.32）μg/L. Serum and urine NGAL were significantly higher in patients with hypertension than the control group（ P〈0.05 ）. The difference between hypertension group and control group in urine β2-mG was statistically significant （ P〈0.05 ）, but not in Scr（ P〉0.05 ）. Conclusion The serum and urine NGAL levels of patients with primary hypertension were significantly higher, detection of serum and urine level of NGAL in hypertension patients may have an important clinical significance in diagnosis, treatment and prognosis of hypertensive nephropathy.