加用甲状腺素片治疗甲亢患者96例的临床观察

Adding Thyroxin in Treatment of 96 Cases of Hyperthyroidism

目的：探讨加用小剂量甲状腺素治疗甲亢患者的·『告床疗效。方法7对收治的甲亢患者96例，随机分为治疗组50例（常规给予抗甲亢药物治疗，甲功正常或接近正常时开始加用小剂量甲状腺素治疗），和对照组46例（给予抗甲亢药物治疗），观察统计两组患者的临床疗效。结果：治疗组50例患者中，甲状腺肿大、突眼症状消退均较快，肥胖和药物性继发性甲状腺功能减退症的发生率较对照组低（P〈0．05），不良反应发生较少。结论：两组治疗均能有效缓解甲亢患者甲状腺功能亢进的高代谢症状，使TSH、TT3、TT4、FT3、FT4恢复正常，但治疗组加用小剂量甲状腺素治疗，能有效地减轻甲状腺肿大、突眼及避免发生药物性继发性甲减，并能减少甲亢的复发，疗效显著，安全。

Objective： To explore the efficacy of extra small dose of thyroxin in treating hyper- thyroidism. Methods： 96 patients with hyperthyroidism were randomly divided into treatment group （50 cases） and control group （46 cases）. Treatment group was added small dose of thyroxin after thyroid function becoming normal or being close to normal on the basis of conventional medicine treatment. Control group were treated by anti-thyroid drug. The efficacy of two groups was ob- served. Results： In treatment group, the symptoms of thyroid enlargement and exophthalmos all fad- ed away faster. The occurrence rate of fat and drug resistance secondary hypothyroidism were lower （P〈0.05）, and the untoward effect was less. Conclusion： Both small dose of thyroxin and anti-thy- roid drug can effective relieve the high metabolic symptoms of hyperthyroidism, and make TSH, TT3, TT4, FT3 and FT4 return to normal. But adding small dose of thyroxin can not only effective alleviate the thyroid enlargement, exophthalmos and avoid drug resistance secondary hypothyroid- ism, but also reduce the recrudescence of hyperthyroidism. The efficacy of it is remarkable and safe.