文拉法辛治疗抑郁症的临床研究

Clinical research of Venlafaxine in treatment of Depression

目的：评价文拉法辛治疗抑郁症的疗效及安全性。方法：将72例抑郁症患者随机分为文拉法辛组和氯丙咪嗪组，采用汉密尔顿抑郁量表（HAMD）、汉密尔顿焦虑量表（HAMA）、副反应量表（TESS）、7临床总体印象量表（CGI）评价疗效和不良反应，并定期检查肝肾功能、心电图、脑电图、血糖及钾、钠、氯等。结果：经6周观察，丈拉法辛与氯丙咪嗪的疗效相当（P〉0．05），但不良反应的发生文拉法辛少于氯丙咪嗪（P〈0．01）。结论：文拉法辛的副反应少而轻，是一种安全有效的抗抑郁药。

Objective： To evaluate the efficacy and safety of venlafaxine in treating depression. Methods： 72 patients with depression were randomly divided into venlafaxine group and clomip- ramine group. The efficacy and untoward effect were evaluated by HAMD, HAMA, TESS and CGI. The kidney function, liver function, ECG, ECT, Blood-Glu and Blood-K, Blood-Na were test- ed at regular intervals. Results： After observing for 6 months, the efficacy of venlafaxine and clo- mipramine was the same （P〉0.05）, but the untoward effect of venlafaxine was less than that of clo- mipramine （P〈0.01）. Conclusions： Venlafaxine is a kind of effective and safe drug in treatment of depression.