子宫内膜异位症术后联合诺雷德治疗模式的探讨

Exploration on Therapy Mode of Endometriosis Postoperative Combining Zoladex

目的：观察子宫内膜异位症腹腔镜手术后应用诺雷德预防复发的临床疗效。方法：我院96例子宫内膜异位症患者均予腹腔镜手术治疗（保留子宫及卵巢），术后随机分为观察组与对照组各48例，观察组术后月经复潮第3～5天给予诺雷德3．6mg皮下注射，之后间隔28天1次，使用3～6个月；对照组术后不给用药；比较两组患者的临床疗效。结果：观察组总有效率明显高于对照组（P〈O．01）；观察组随访复发率低于对照组（P〈O．01），随访妊娠率高于对照组（P〈O．01），均具有统计学意义；观察组用药期间未见明显不良反应。结论：子宫内膜异位症腹腔镜手术后给予诺雷德持续治疗可提高手术治疗效果、降低术后短期复发率、提高术后妊娠率，临床用药安全性高，值得推广应用。

Objective： To observe clinical curative effects of applying Zoladex to prevent endometriosis relapse after laparoscopic operation. Meth otis： 96 cases were randomly divided into observation group and control group after the operation, each of 48, the observation group was given zola dex with subcutaneous injection of 3.6mg after the 3rd5th days of menstruation, afterwards every 28 days a time, lasting 36 months; control group wasn＇t given medication after surgery; to compare the clinical curative effects of two groups. Results： The total effective rate in observation group was significantly higher than that in control group （P〈0.01）; recurrence rate of observation group was lower than that of the control group （P〈0.01）, followingup pregnancy rate was higher than that of control group （P〈0.01）, all of which were statistically significant; there was no significant ad verse reactions in observation group during the medication. Conclusion： Postoperative continued medication of zoladex can improve the curative ef fects, reduce the postoperative shortterm recurrence rate and improve the pregnancy rate after endometriosis laparoscopic operation, it is highsafety medication in clinic, being worthy of popularization and application.