摘要
根据人体免疫系统昼夜节律的实验数据 ,提出了皮质醇作用于T淋巴细胞再循环过程途径的假设 ,建立了皮质醇作用下的人体T细胞在淋巴器官与血液之间再循环过程的数学模型。讨论了皮质醇作用的强度及其它再循环参量的取值范围及理论结果对参数的敏感性。模型能够较好地解释再循环的T淋巴细胞在淋巴器官与血液中的稳定振荡行为 ,得到的数值模拟结果与免疫系统生物节律实验结果相符合。
Based on circadian rhythms experimental data of human immune system, assumptions of the possible pathways of cortisol influencing on T lymphocyte recirculation are proposed. The authors present a mathematical model of human T lymphocytes recirculation considering the influence of plasma cortisol level. The intensity of the action of cortisol and the sensitivity of the results to important parameters are discussed. The model can be used to explain the stationary oscillation behaviour of T lymphocytes in lymphoid tissues and blood. The numerical results are in agreement with human immune circadian rhythm experimental data.
出处
《生物物理学报》
CAS
CSCD
北大核心
2000年第3期586-594,共9页
Acta Biophysica Sinica
基金
国家自然科学基金NSFC资助项目!(No.39370184)
关键词
免疫系统
昼夜节律
T细胞再循环
皮质醇
Immune circadian rhythms
T lymphocytes recirculation
Plasma cortisol level
Mathematical model
