萘普生栓联合吗啡硬膜外镇痛用于剖宫产术后镇痛的临床观察

Role of naproxen suppository and morphine epidural analgesia in post-cesarean analgesia

目的观察萘普生栓联合吗啡硬膜外镇痛在剖宫产术后镇痛效果。方法将123例剖宫产产妇随机分成萘普生栓联合吗啡硬膜外镇痛组(NM组,61例)和单纯吗啡硬膜外镇痛组(M组,62例),比较两组间术后4、8、12、24hVAS评分、以及24h内镇痛泵按压次数和不良反应发生情况。结果 NM组术后4、8、12、24hVAS评分、以及24h内镇痛泵按压次数均明显低于M组(P<0.01或0.05),两组间不良反应差异无统计学意义(P>0.05)。结论萘普生栓联合吗啡硬膜外镇痛在剖宫产术后镇痛效果明显,值得临床应用。

Objective To observe the clinical efficacy of naproxen suppository and morphine epidural analgesia in post-cesarean pain. Methods A total of 123 pregnant women undergoing cesarean were randomly allocated to naproxen suppositoryplus morphine epidural analgesia （NM group, n=61） or morphine epidural analgesia alone （M group, n=62）. VAS scores at 4 h, 8h, 12 h and 24 h, pressing times of analgesia pump within 24 h and adverse events were compared between both groups. ResultsVAS scores at all timepoints and pressing times of analgesia pump within 24 h were lower in NM group than those in M group（P0.01 or 0.05）, but there was no difference in adverse events between both groups （P0.05）. Conclusion Naproxensuppository plus morphine epidural analgesia is effective for post-cesarean pain and may be worthy of clinical application.