环境内分泌干扰物的评价方法及其生物检测技术

Assessment Methods and Biological Detection Techniques for Environmental Endocrine Disruptors (EDCs)

由于化学分析设备与技术的不断提高,大量的有机化学物质不断地从环境介质和食品中被检出。尽管这些物质的浓度很低,但是毒理学的研究表明,一些环境内分泌干扰物质(Environmental Endocrine Disruptors,EDCs)在很低浓度就能导致生物健康负效应。如何在种类众多的环境化学物质,以及在成分复杂的环境提取物中识别具有低剂量效应的有害物质并加以管理十分重要。本文以EDCs为对象,结合近几年来的文献,综述了其可能造成的危害,重点分析了EDCs的作用机制、筛选评估方法及生物检测技术,旨在为今后环境有害物质的筛选与风险识别研究提供借鉴。

With the rapid development of analysis instruments and techniques,many organic chemicals have been frequently detected in various environmental media and foods in recent years.Their concentration level is low,and toxicological studies show that some of them might cause adverse effect to living organisms even at such a low concentration,especially for Environment Endocrine Disruptors （EDCs）.It is very important to successfully identify and manage these low-level harmful chemicals in complex environment samples.Taking EDCs as study objects,the potential risks of EDCs are summarized based on literature research in recent years,especially for the mechanisms of action,evaluation criteria and biological detection techniques of different EDCs,which will contribute to the screening and risk identification of harmful materials in environment.