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膜型基质金属蛋白酶-1作用的研究进展 被引量：2

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摘要 膜型基质金属蛋白酶-1(membrane type 1 matrix metalloproteinase,MT1-MMP)是基质金属蛋白酶(matrix metalloproteinase,MMPs)家族中表达于细胞膜表面的新成员。MT1-MMP参与细胞外基质的降解和重塑、细胞内信号转导、骨代谢等生理过程;在肿瘤侵袭及扩散、血管新生及动脉粥样硬化、关节炎等病理过程中也发挥了重要的作用;同时,与口腔的许多疾病有着密不可分的关系。因此,研究MT1-MMP的作用对我们了解体内的多种疾病的发病机制及治疗方法具有重要的指导意义。
作者 武蕾 王景云
机构地区 吉林大学口腔医院修复科
出处 《中华老年口腔医学杂志》 2012年第5期309-311,共3页 Chinese Journal of Geriatric Dentistry
关键词 膜型基质金属蛋白酶-1 生理过程 病理过程 口腔疾病
分类号 R780.2 [医药卫生—口腔医学]
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参考文献21

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  • 2Denis Gingras,Richard Béliveau.Emerging concepts in the regulation of membrane-type 1 matrix metalloproteinase activity[J].Molecular Cell Research,2010,1803(1):142-150.
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  • 5Takino T,Miyamori H,Watanabe Y,et al.Membrane type 1 matrix metalloproteinase regulates collagen-dependent mitogen-activated protein/extracellular signal-related kinase activation and cell migration[J].Cancer Research,2004,64(3):1044-1049.
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同被引文献23

  • 1Park CS,Kim SH,Jung SL,et al.Observer variability in the sonographic evaluation of thyroid nodules[J].J Clin Ultrasound,2010,38(6):287-293.
  • 2Clark OH.Thyroid cancer and lymph node metastases[J].J Surg Oncol,2011,103(6):615-618.
  • 3Sun M,Fang S,Li W,et al.Associations of miR-146a and miR-146b expression and clinical characteristics in papillary thyroidcarcinoma[J].Cancer Biomark,2015,15(1):33-40.
  • 4Yadav L,Puri N,Rastogi V,et al.Matrix metalloproteinases and cancer-roles in threat and therapy[J].Asian Pac J Cancer Prev,2014,15(3):1085-1091.
  • 5Fink K,Boratyński J.T e role of metalloproteinases in modif cation of extracellular matrix in invasive tumor growth,metastasis and angiogenesis[J].Postepy Hig Med Dosw(Online),2012,66(7):609-628.
  • 6Jun HH,Kim SM,Kim BW,et al.Overcoming the limitations of fine needle aspiration biopsy:detection of lateral neck node metastasis in papillary thyroid carcinoma[J].Yonsei Med J,2015,56(1):182-188.
  • 7Oyarzún A,Arancibia R,Hidalgo R,et al.Involvement of MT1-MMP and TI MP-2 in human periodontal disease[J].Oral Dis,2010,16(4):388-395.
  • 8Lovaas JD,Zhu L,Chiao CY,et al.SIRT1 enhances matrix metalloproteinase-2 expression and tumor cell invasion in prostate cancer cells[J].Prostate,2013,73(5):522-530.
  • 9Li QS,Chen SH,Xiong HH,et al.Papillary thyroid carcinoma on sonography[J].Clin Imaging,2010,34(2):121-126.
  • 10Nagase H,Visse R,Murphy G.Structure and function of matrix metalloproteinases and TIMPs[J].Cardiovasc Res,2006,69(3):562-573.

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中华老年口腔医学杂志
2012年 第5期

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