期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

与慢性病理性疼痛相关的中枢神经GABA_A受体和NMDA受体的交互作用

下载PDF
导出
摘要 各种疾病引起的慢性疼痛严重影响患者的身心健康,而疼痛信息传递和痛觉神经系统中的相关神经递质密切相关,N-甲基-D-门冬氨酸(N-methyl-D-asnartate,NMDA)受体和γ-氨基丁酸A型(γ-Aminobutyricacid,GABAA)受体作为中枢神经系统中重要的兴奋性和抑制性受体,通过和其在痛觉神经元突触胞膜上的特异性神经递质相结合传递,调制相关痛觉信息。新近有学者通过电生理和形态学等方法研究发现,神经元突触胞膜上NMDA受体和GABAA受体在慢性痛觉信息传递过程中发挥各自作用的同时,两种受体之间有着广泛的分子生物化学等信息交流,在传递痛觉信息过程中有明显的交互作用,通过总结上述两种受体在痛觉信息传递过程中相互调控机制,能够为进一步临床上治疗慢性病痛提供新的思路和方法。
作者 栗洪师 刘洪臣
机构地区 解放军总医院口腔医学研究所
出处 《中华老年口腔医学杂志》 2012年第6期350-354,共5页 Chinese Journal of Geriatric Dentistry
基金 国家自然科学基金(编号:30772450)
关键词 GABAA受体 NMDA受体 慢性病理性疼痛
分类号 R363 [医药卫生—病理学]
  • 相关文献

参考文献48

  • 1Bleakman D,Alt A,Nisenbaum ES.Glutamate receptors and pain[J].Semin Cell Dev.Biol,2006,17:592-604.
  • 2Nagy GG,Watanabe M,Fukaya M,et al.synaptic distribution of the NR1,NR2A and NR2B subunits of the N-methyl-d-aspartate receptor in the rat lumbar spinal cord revealed with an antigen-unmasking technique[J].Eur J Neurosci,2004,20:3301-3312.
  • 3Perez-Otano I,Ehlers MD.Learning from NMDA receptor trafficking:clues to the development and maturatioin of glutamatergicsynapses[J].Neurossignals,2004,13:175-189.
  • 4Paoletti P,Neyton.NMDA receptor subunits:function and pharmacology[J].CurrOpinPharmacol,2007:39-47.
  • 5Lau CG,Zukin RS.NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders[J].Nat Rev Neurosci,2007,8:413-426.
  • 6South SM,Kohno T,Kaspar BK,et al.A conditional deletion of the NRI subunit of the NMDA receptor in adult spinal cord dorsal horn reduces NMDA currents and injury-inducedpain[J].J Neurosci,2003,23:5031-5040.
  • 7Shimoyama N,Shimoyama M,Davis AM,et al.An antisense oligonucleotide to the N-methyl-D-aspartate (NMDA) subunit NMDAR1 attenuates NMDA-induced nociception,hyperalgesia,and morphine tolerance[J].J Pharmacol Exp Ther 2005,312:834-840.
  • 8朱美玲,刘洪臣,郝作琦,等.咬合创伤大鼠SpVc NMDAR 1的表达[J].口腔领面修复学杂志,2002,3(4):215-218.
  • 9Malmberg AB,Yaksh TL.Spinal nitric oxide synthesis inhibition blocksNMDA-induced thermal hyperalgesia and produces antinociception in the formalin test in rats[J].Pain 1993,54:291-300.
  • 10Sato E,TakanoY,Kuno Y,et al.Involvement of spinal tyrosine kinase in inflammatory and N-methyl-D-aspartate-induced hyperalgesia in rats.Eur[J].J Pharmacol,2003,468:191-198.

二级参考文献38

  • 1Nakazawa K, Inoue K, Koizumi S. Facilitation by 5-hydroxytryptamine of ATP-activated current in rat pheochromocytoma cells. Pflugers Arch, 1994, 427:492-499.
  • 2Xu T L, Li J S, Jin Y H, et al. Modulation of the glycine response by Ca^2+-permeable AMPA receptors in rat spinal neurones. J Physiol, 1999, 514(Pt3): 701-711.
  • 3Lee F J, Xue S, Pei L, et al. Dual regulation of NMDA receptor functions by direct protein-protein interactions with the dopamine D1 receptor. Cell, 2002, 111:219-230.
  • 4Li Y, Wu L J, Legendre P, et al. Asymmetric cross-inhibition between GABAA and glycine receptors in rat spinal dorsal horn neurons. J Biol Chem, 2003, 278:38637-38645.
  • 5Hollmann M, Heinemann S. Cloned glutamate receptors. Annu Rev Neurosci, 1994, 17:31-108.
  • 6Seeburg P H. The TINS/TiPS Lecture. The molecular biology of mammalian glutamate receptor channels. Trends Neurosci, 1993, 16: 359-365.
  • 7Harvey R J, Depner U B, Wassle H, et al. GlyR alpha3: an essential target for spinal PGE2-mediated inflammatory pain sensitization. Science, 2004, 304:884-887.
  • 8Ahmadi S, Lippross S, Neuhuber W L, et al. PGE(2) selectively blocks inhibitory glycinergic neurotransmission onto rat superficial dorsal horn neurons. Nat Neurosci, 2002, 5:34-40.
  • 9Casseday J H, Ehrlich D, Covey E. Neural tuning for sound duration: role of inhibitory mechanisms in the inferior colliculus. Science, 1994, 264:847-850.
  • 10Brand A, Behrend O, Marquardt T, et al. Precise inhibition is essential for microsecond interaural time difference coding. Nature, 2002, 417: 543-547.

共引文献6

中华老年口腔医学杂志
2012年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部