110例药品不良反应汇总分析

Analysis of 110 adverse grug reactions

目的通过对我院2012年收集的110例不良反应报告汇总,分析药物不良反应(ADR)发生情况、发生特点及相关因素;通过对ADR上报范围及趋势的分析,进一步促进我院ADR监测工作的进步。方法采用病例回顾性研究的方法,总结药品不良反应发生特点及上报特点。结果 14岁以下及45岁以上年龄段占比例较高;男性与女性ADR发生率大致相同;静脉滴注给药途径引起ADR的比例较高;涉及的药品以抗肿瘤药物、抗菌药物和中成药制剂居多;2012年ADR上报数量及质量较往年显著提高,药师上报ADR数量居首。结论药品不良反应发生率受人口学因素、给药途径、药品差异等多种因素影响,临床应用中应以患者为中心,充分发挥医、护、药多种职业的协同优势,加强防患意识,做好药品不良反应的监测和上报工作,为临床合理用药提供支持。

Objective： To analyze adverse drug reaction（ADR） occurrence,occurrence characteristics and related factors through the summary of 110 adverse reaction reports collected in 2012 in our hospital and to explore ADR reported range and trend analysis to further promote our hospital ADR monitoring progress.Methods： A retrospective study summarized the characteristics and reporting of adverse drug reactions and occurrence characteristics.Results： Ages under the age of 14 and over the age of 45 accounted for a higher proportion;men and women ADR incidence were roughly the same;intravenous route of administration caused a higher proportion of ADR;drugs involved were anticancer drugs and the main were antibacterial drugs and Chinese medicine formulations;the quantity and quality of the ADR reported in 2012 significantly improved than those in previous years,with the pharmacists reported ADR quantity on the top.Conclusion： The incidence of adverse drug reactions is affected by a variety of factors of demographic factors,route of administration and drug differences.Clinical applications should be patient-centered,and a full play should be given to the synergy advantages of a variety of occupational medicine,nursing and medicine,anticipatory awareness should be strengthened,a better job of the monitoring and reporting of adverse drug reactions should be done to provide support for the clinical use of drugs.