中药口服和穴位贴敷法对慢性阻塞性肺疾病稳定期肺功能及免疫功能的影响

Effect of Oral Medicine and Acupoint Sticking Therapy on Pulmonary Function and Immune Function in Chronic Obstructive Pulmonary Disease in Stable Period

目的评价内服补肾固本颗粒联合外敷麻芥消喘膏治疗慢性阻塞性肺疾病稳定期患者,观察其对肺功能及免疫功能的影响。方法 60例患者随机分为治疗组和对照组,两组均采用支气管舒张剂和祛痰药物进行基础治疗,治疗组除基础治疗外,加用内服补肾固本颗粒,外治法采用麻芥消喘膏贴敷,对照组除基础治疗外,另服百令胶囊,外治法采用安慰剂贴敷。两组治疗均已3月为1周期。结果治疗组30例中,临床控制8例,显效15例,有效6例,总有效率96.67%;对照组30例中,临床控制3例,显效8例,有效10例,总有效率70.00%。两组总有效率比较有显著性差异(P<0.05),治疗组疗效明显优于对照组。治疗组和对照组CD3、CD4、CD4/CD8升高,CD8下降,两组有显著性差异(P<0.05)。结论中医内服外治法治疗慢性阻塞性肺疾病稳定期具有较好地改善患者临床症状,改善其肺功能,且使免疫功能明显改善。

Objective To evaluate-the strengths of Bushen Guben Particle combined Majie Xiaochuan cream treatment on the 60 cases patients of the chronic obstructive pulmonary disease in stable period, observed lung function and immune function. Methods 60 patients were ran- domly divided into treatment and control groups, two groups are used bronchodilator and expectorant drug therapy, the treatment group in addition to basic treatment, plus oral Bushen Guben particles, External use of Majie Xiaochuan cream sticking in the control group in addition to basic treatment, the other serving Bailing capsule, External placebo patching. Both of two groups have 3 months for the 1 cycle. Results The treatment group 30 cases, clinical control in 8 cases, 15 cases markedly effective, the total efficiency is 96. 67 % ; the control group of 30 patients, the clinical control in 3 cases, markedly effective in 8 cases, effective in 10 cases, the total efficiency is 70.00% .The total efficiency of two groups had significant difference（ P〈0. 05）, the curative effect of treatment group was better than the control group. There was significant difference between two groups, treatment and control groups CD3, CD4,CD4/CD8 increased, CD8 down（ P〈0.05）. Conclusion Oral med- icine and external treatment of chronic obstructive pulmonary disease have good improvement in stable patients with clinical symptoms, im- prove lung function, and make significant improvement in immune function.