乳腺癌化疗现状及相关研究进展

The Current Situation and Related Progress in the Study of Breast Cancer Chemotherapy

乳腺癌是除非上皮来源肿瘤中女性最常见的恶性肿瘤,在美国平均每3名女性中就有一名患乳腺癌,是女性肿瘤致死中的第二大原因,给政府经济造成了很大的损失。目前,乳腺癌主要是以手术治疗为主,而化疗,放疗等也作为相当重要的辅助治疗应用于临床。这种手术加化疗的治疗方法一直可以取得很好的疗效,甚至于可以保住乳房。近年来,乳腺癌的化疗已逐步成为其治疗的首选方式,包括术后辅助化疗和术前的新辅助化疗。但由于化疗药物的滥用和肿瘤本身的异质性或是其他原因,越来越多的肿瘤耐药性报道给乳腺癌的化疗带来了很大的挑战。而这种肿瘤耐药性的分子机制尚不是很清楚。本文将从乳腺癌的概述,乳腺癌化疗的现状及乳腺癌化疗的前景来综述这一灾难性疾病。

Excluding skin cancers,breast cancer is the most common malignancy among women,accounting for nearly 1 in 3 cancers diagnosed among women in the United States,and it is the second leading cause of cancer death among women;besides,it brings a great financial lost of government.At present,surgery is the main treatment for the disease and chemotherapy or radiotherapy have also become important adjuvant therapies in clinical.This treatment binding surgery and chemotherapy treatments has got a very good curative effect,even can protect from removing the breast.Recent years,chemotherapy has become the preferred way to treat breast cancer,including adjuvant chemotherapy after surgery and neoadjuvant chemotherapy before surgery.However,as the inadaptable ways or other unknown mechanisms,more and more drug resistance have been reported and this brings a great challenge to the therapy of the disease.This review will cover the introduction of breast cancer,the current situation and prospect of this disasters＇ chemotherapy.