Genetic variants in telomere-maintenance genes and bladder cancer risk

端粒维持基因多态性与膀胱癌易感性的关系(英文)

下载PDF

导出

摘要 Telomere maintenance genes play an important role in maintaining the integrity of the telomere structure that protects chromosome ends,and telomere dysfunction may lead to tumorigenesis.Genetic variation in telomere maintenance genes has been confirmed.Cumulative evidence shows that the difference of telomere length and stability among the individual depends on the genetic variants of telomere maintenance genes.Genetic variants in telomere maintenance genes may affect telomere length and stability,thus the increased cancer risk.This review intends to summarize the association of genetic variants in telomere maintenance genes with bladder cancer risk.

作者 Chengyuan Gu Yao Zhu Dingwei Ye

机构地区 Department of Urology Department of Oncology

出处《The Chinese-German Journal of Clinical Oncology》 CAS 2013年第9期448-453,共6页 中德临床肿瘤学杂志（英文版）

关键词 telomere maintenance genes polymorphism bladder cancer susceptibility 端粒长度遗传变异膀胱癌基因风险维护功能障碍稳定性

分类号 R737.14 [医药卫生—肿瘤]

引文网络
相关文献

参考文献63

1Harley CB. Telomerase and cancer therapeutics. Nat Rev Cancer, 2008, 8: 167-179.
2Palm W, de Lange T. How shelterin protects mammalian telomeres. Annu Rev Genet, 2008, 42: 301-334.
3Griffith J, Comeau L, Rosent]eld S, et al. Mammalian telomeres end in a large duplex loop. Cell, 1999, 97: 503-514.
4Aubert-G, Lansdorp'P. Tel0meres and aging. Physiol Rev, 2008, 88: 557-579.
5Klapper W, Parwaresch R, Krupp G. Telomere biology in human ag- ing and aging syndromes. Mech Ageing Dev, 2001, 122: 695-712.
6Stewart S-A, VVeinberg RA. Telomeres: cancer to human aging. Semin Cancer Biol, 2000, 10: 399-406.
7Wise J, CroutR, McNeil D, et al. Human telomere length correlates to the size of the associated chromosome arm. PLoS One, 2009, 4: e6013.
8Aviv A, Chen W, Gardner J, et al. Leukocyte telomere dynamics: lon- gitudinal findings among young adults in the Bogalusa Heart Study. Am J Epidemiol, 169: 323-329.
9Niajou(),-Cahon-R, D-a-rncottC, et al. Telornere length is paternally inherited and is associated with parental lifespan. Proc Natl Acad Sci USA, 104: 12135-12139.
10Shay JW, Wright WE. Role of telomeres and telomerase in cancer. Semin Cancer Biol, 2011, 21: 349-353.

1Sijun Liu,Yun Qian,Feng Lu,Meihua Dong,Yudi Lin,Huizhang Li,Chong Shen,Juncheng Dai,Yue Jiang,Guangfu Jin,Zhibin Hu,Hongbing Shen.Genetic variants at 10q 23.33 are associated with plasma lipid levels in a Chinese population[J].The Journal of Biomedical Research,2014,28(1):53-58. 被引量：1
2Cong Huang,Wei Liu,Gui-Xiang Ji,Ai-Hua Gu,Jian-Hua Qu,Ling Song,Xin-Ru Wang.Genetic variants in TP53 and MDM2 associated with male infertility in Chinese population[J].Asian Journal of Andrology,2012,14(5):691-694. 被引量：4
3Jing-zhe Sun,Xue-xi Yang,Ni-ya Hu,Xin Li,Fen-xia Li,Ming Li.Genetic Variants in MMP9 and TCF2 Contribute to Susceptibility to Lung Cancer[J].Chinese Journal of Cancer Research,2011,23(3):183-187. 被引量：4
4Yi-ming YUAN,Jin-Iong ZHANG,Si-cheng XU,Ren-song YE,Dan XU,You ZHANG,Yan-Jie ZHANG,Yu-Iong CHEN,Yu-lan LIU,Zhi-guang SU.Genetic variants of CDH13 determine the susceptibility to chronic obstructive pulmonary disease in a Chinese population[J].Acta Pharmacologica Sinica,2016,37(3):390-397. 被引量：1
5WANG Fang HAN Xue-yao REN Qian ZHANG Xiu-ying HAN Ling-chuan LUO Ying-ying ZHOU Xiang-hai JI Li-nong.Effect of genetic variants in KCNJ11, ABCC8, PPARG and HNF4A loci on the susceptibility of type 2 diabetes in Chinese Han population[J].Chinese Medical Journal,2009(20):2477-2482. 被引量：11
6Yi Guo,Jing Fang,Yan Liu,Hai-Hui Sheng,Xiao-Yan Zhang,Hai-Na Chai,Wei jin,Ke-Hao Zhang,Chang-Qing Yang,Heng-jun Gao.Association between polymorphism rs6983267 and gastric cancer risk in Chinese population[J].World Journal of Gastroenterology,2011,17(13):1759-1765. 被引量：5
7Ting-Ting Li,Hong Qiao,Hui-Xin Tong,Tian-Wei Zhuang,Tong-Tong Wang.Association of Common Genetic Variants in Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 with Type 2 Diabetes Mellitus in a Chinese Han Population[J].Chinese Medical Journal,2016(10):1179-1184. 被引量：1
8Min Zhang,Yan Zhang,Shuaishuai Zhu,Xiaoyu Li,Qing Yang,Hui Bai,Qi Chen.Genetic variants of the class A scavenger receptor gene are associated with coronary artery disease in Chinese[J].The Journal of Biomedical Research,2012,26(6):418-424.
9张万金,王晓平,沈琼,罗艳.溴匹利明的合成研究[J].广东化工,2006,33(4):13-14. 被引量：1
10Jia Sun,Yuting Yang,Ke Wan,Ninghui Mao,Tai-Yuan Yu,Yi-Chien Lin,Diane C DeZwaan,Brian C Freeman,Jing-Jer Lin,Neal FLue,Ming Lei.Structural bases of dimerization of yeast telomere protein Cdc13 and its interaction with the catalytic subunit of DNA polymerase a[J].Cell Research,2011,21(2):258-274. 被引量：1

The Chinese-German Journal of Clinical Oncology

2013年第9期

浏览历史

内容加载中请稍等...

Genetic variants in telomere-maintenance genes and bladder cancer risk

参考文献63

相关作者

相关机构

相关主题

浏览历史