氟摄入对胃肠道及其粪钙排出的影响

Effect of Sodium Fluoride Ingestion on Gastrointestial Tract and Ca Excretion in Faeces of Mice

本研究给 72只小鼠不同浓度的饮水加氟 ,剂量 2 5 /L～ 1 0 0 /L ,以了解氟对消化道的影响以及氟对粪钙排出的影响。在给氟 5 0d时 ,粪钙在不同加氟组间未见明显差别。给氟 90d时 ,胃肠粘膜观察到不同程度的灶性坏死脱落 ,十二指肠粘膜部分绒毛溶解 ,上皮变性坏死。表明一定剂量氟可对上消化道粘膜产生强烈刺激与损伤 。

This paper employed 72 mice given different fluoride concertration from 25 /L to 100 /L in drinking water to investigate effect of fluoride ingestion on gastrointestinal tract and on calcium excretion in faeces.At 50 days of experiment ,calcium levels in faeces of different water fluoride groups did not show significant differences .In the end of 90 days,histopathological examination revealed local necrosis and desquamation of gastric mucosa ,disolved villi and degenerated epithelia of duodenal mucosa. The findings demostrated that the gastrointestinal mucosa is severely irratated and damaged by the toxic effects of high fluoride dose ,resulting in gastrointestinal symptoms such as anorexia.