肝素对金黄色葡萄球菌与血浆蛋白间粘附的阻断作用

Heparin Blocks the Adhesion of Staphylococcus Aureus

金黄色葡萄球菌与宿主细胞粘附是其感染的先决条件。若能阻断粘附环节,金黄色葡萄球菌将无法生长繁殖,即可降低由其引发的疾病的发病率。本研究采用静止粘附技术等实验手段,研究肝素对金黄色葡萄球菌与血浆蛋白粘附的阻断。结果显示,当肝素溶液浓度<1.0 mg/mL时,肝素以浓度依赖的方式阻断。金黄色葡萄球菌粘附血浆蛋白后,淋巴细胞对其吞噬作用减弱;加入肝素后,吞噬作用的强度增强。结果暗示,肝素能够阻断金黄色葡萄球菌与血浆蛋白的粘附,可以作为临床药物开发的靶点。

The prerequisite for infection of Staphylococcus aureus is the adhesion between Staphylococcus aureus and host cells. If we can block the adhesion links, S. aureus will not be able to live and breed, thus we can reduce the disease caused by S. aureus. In this study, we use the experimental means of static adhesion technology to study how heparin blocks the adhesion between S. aureus and plasma proteins. The results show that heparin blocks the adhesion in concentration dependent manner when the concentration is lower than 0.5 mg/mL. After the adhesion of S. aureus to plasma protein, the phagocytosis of lymphocytes reduced. But the phagocytosis intensity increases gradually after adding heparin solution. The results show that heparin can block the adhesion between Staphylococcus aureus and plasma proteins. It can be used as a target to develop new drugs.