摘要
目的:探讨2型糖尿病周围神经病变(DPN)的发生率和危险因素。方法:住院的2型糖尿病患者197例,年龄(54.95±10.27)岁,病程(6.45±3.81)年。经神经电生理检查诊断DPN,观察DPN的发生率,应用多因素Logistic回归分析,探讨DPN的危险因素。结果:(1)197例中检出DPN患者170例,患病率高达86.29%,MCV异常率(83.25%)高于SCV(73.10%)(X2=3.95,P<0.05)。(2)DPN组年龄(55.83±10.31)岁,病程(7.97±4.75)年,血肌酐(71.28±37.77)μmol/L,治疗后空腹血糖(7.41±1.53)mmol/L均高于NDPN组(P<0.05或0.01)。(3)多因素Logistic回归分析显示病程(P<0.01)、总胆固醇(P=0.02)、低密度脂蛋白(P=0.05)和糖化血红蛋白(P=0.05)是DPN的危险因素。结论:DPN发生率高,严格控制血糖、血脂等代谢因素对DPN的预防有重要意义。
Objective:To explore the incidence and risk factors for type 2 diabetic peripheral neuropathy.Method:197 cases of hospitalized patients with type 2 diabetes,aged(54.95±10.27)years old,and a duration of(6.45±3.81)years.DPN was diagnosed by neurophysiological examination,to observe the incidence of DPN,and use multivariate Logistic regression analysis to explore the risk factors of DPN.Result:(1)In 197 patients 170 cases were detected with DPN,the prevalence rate as high as 86.29%,and the MCV abnormal rate(83.25%) was higher than the SCV(73.10%)(X2 =3.95, P 0.05).(2)The age (55.83±10.31) years old,duration (7.97±4.75) years,serum creatinine (71.28±37.77) μmol/L and fasting blood glucose after treatment (7.41±1.53) mmol/L of DPN group were higher than NDPN group (P 0.05 or 0.01).(3)Multivariate Logistic regression analysis showed that the risk factors of DPN include the course of the disease(P 0.01), total cholesterol(P =0.02),LDL(P =0.05),and HbA1c(P =0.05).Conclusion:The incidence of DPN is high,and strict control of blood sugar,blood lipids and other metabolic factors is important for the prevention of DPN.
出处
《中外医学研究》
2013年第24期1-3,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
基金
保定市科学技术研究与发展指导计划(项目编号:11ZF100)