2型糖尿病周围神经病变及其危险因素分析

Type 2 Diabetic Peripheral Neuropathy and its Risk Factors Study

目的:探讨2型糖尿病周围神经病变(DPN)的发生率和危险因素。方法:住院的2型糖尿病患者197例,年龄(54.95±10.27)岁,病程(6.45±3.81)年。经神经电生理检查诊断DPN,观察DPN的发生率,应用多因素Logistic回归分析,探讨DPN的危险因素。结果:(1)197例中检出DPN患者170例,患病率高达86.29%,MCV异常率(83.25%)高于SCV(73.10%)(X2=3.95,P<0.05)。(2)DPN组年龄(55.83±10.31)岁,病程(7.97±4.75)年,血肌酐(71.28±37.77)μmol/L,治疗后空腹血糖(7.41±1.53)mmol/L均高于NDPN组(P<0.05或0.01)。(3)多因素Logistic回归分析显示病程(P<0.01)、总胆固醇(P=0.02)、低密度脂蛋白(P=0.05)和糖化血红蛋白(P=0.05)是DPN的危险因素。结论:DPN发生率高,严格控制血糖、血脂等代谢因素对DPN的预防有重要意义。

Objective：To explore the incidence and risk factors for type 2 diabetic peripheral neuropathy.Method：197 cases of hospitalized patients with type 2 diabetes,aged（54.95±10.27）years old,and a duration of（6.45±3.81）years.DPN was diagnosed by neurophysiological examination,to observe the incidence of DPN,and use multivariate Logistic regression analysis to explore the risk factors of DPN.Result：（1）In 197 patients 170 cases were detected with DPN,the prevalence rate as high as 86.29%,and the MCV abnormal rate（83.25%） was higher than the SCV（73.10%）（X2 =3.95, P 0.05）.（2）The age （55.83±10.31） years old,duration （7.97±4.75） years,serum creatinine （71.28±37.77） μmol/L and fasting blood glucose after treatment （7.41±1.53） mmol/L of DPN group were higher than NDPN group （P 0.05 or 0.01）.（3）Multivariate Logistic regression analysis showed that the risk factors of DPN include the course of the disease（P 0.01）, total cholesterol（P =0.02）,LDL（P =0.05）,and HbA1c（P =0.05）.Conclusion：The incidence of DPN is high,and strict control of blood sugar,blood lipids and other metabolic factors is important for the prevention of DPN.