早期发现中老年人餐后血糖异常的影响因素分析

Analysis of factors associated with the early detection of abnormal glucose tolerance among middle aged and elder population

目的为了解代谢综合征(MS)、腹部肥胖、空腹血糖升高与餐后血糖异常的关系,提示中老年人餐后血糖异常(AGT)的风险,为早期发现糖尿病提供指导。方法横断面研究,分别用美国NCEP和国际糖尿病联盟的标准诊断MS。结果共有632例参加者,AGT检测率为34.02%。MS和空腹血糖升高可使AGT的风险增加3倍多,OR(95%CI)分别为3.09(2.18～4.40)和3.20(2.24～4.56)。腹部肥胖使AGT的风险增加2倍多,OR(95%CI)为2.07(1.43～2.99)。随着MS指标数聚集数的增多,AGT的危险随之增高。在血糖正常的情况下,MS指标聚集数依然有增加AGT风险的趋势。结论 MS、空腹血糖升高、腹部肥胖的人群当及时进行餐后血糖检测,以早期发现糖尿病风险。

Objective To analyze the association of metabolic syndrome （MS） and central obesity as well as impaired fasting glucose （IFP） with abnormal glucose tolerance （AGT） among urban middle-aged and elder population, in order to improve the early detection of Type 2 diabetes. Methods A cross-sectional study was conducted. MS was determined based on diagnostic standards proposed by the National Cholesterol Education Program （NCEP） and the International Diabetes Federation （IDF）. Results A total of 632 eligible subjects were enrolled in the study and the overall AGT was 34%. Individuals with MS or elevated fasting glucose level were over 3 times more likely to have AGT compared with their counterpart （OR=3.09, 95%CI： 2.18-4.40; OR=3.20, 95%CI： 2.24-4.56）, while those with central obesity were over 2 times more likely to have AGT （OR= 2.07, 95% CI= 1.43 2.99） . More MS indicators combined together could indicate a higher risk of AGT. Even without IFG in the cluster, an increased odds ratio was still observed. Conclusions MS and its components are associated with the increased probability of AGT. MS, IFP and central obesity are risk factors of AGT.