复方丹参滴丸治疗早期糖尿病肾病的临床疗效及安全性评价

The clinical curative effect and safety evaluation of Compound Danshen Driping Pills in the treatment of diabetic nephropathy

目的探讨复方丹参滴丸对早期糖尿病肾脏病变的临床治疗效果及安全性评价。方法将血压正常的90例早期糖尿病肾病患者随机分为对照组和治疗组。对照组予以控制血糖、糖尿病教育等常规治疗;治疗组在常规治疗的基础上加用复方丹参滴丸15粒,3次/d,均治疗12周。完成治疗后观察患者尿微量白蛋白、肝功能、血尿常规等指标以评价其临床疗效和安全性。结果治疗组患者尿微量白蛋白较治疗前明显下降,具有统计学意义(P<0.01),与对照组比较具有统计学意义(P<0.05),而两组患者肝肾功能、血尿常规等差异无统计学意义(P>0.05)。结论复方丹参滴丸能有效改善早期糖尿病肾病患者的尿微量白蛋白水平,临床治疗效果明显,且药物使用安全性较高,在临床中可以推广应用。

Objective To observe the clinical curative effect and safety evaluation of Compound Dan-shen dripping Pills（ CDDP） in the treatment of early stage of Diabetic Nephropathy. Methods Ninety patients who blood pressure is in the normal range were divided into control group and treatment group,All of them were given control blood glucose,diabetic education,conventional treatment and so on. While those in treatment group,besides of treatment as control group,were given CDDP,15 pills,3 times a day,All treatment course were 12weeks. To observe the chance of urine microalbumin,liver and kidney function,routine blood and urine after treatment,Then evaluate the clinical curative effect and safety. Results After 12 weeks treatment,the level of urine microalbumin were lower than those before and control group significantly,but liver function,routine blood and urine weren’t obvious difference in both groups. Conclusion CDDP can improve the level of urine microalbumin in the early stage of diabetic nephropathy,the effect of clinical treatment is significantly,and the safety is higher,then can be applied in clinical safety.