中药内服外敷治疗类风湿关节炎临床研究

Clinical Research of Chinese Medicine Internal and External Treatment for Rheumatoid Arthritis

目的:观察中药内服外敷治疗类风湿关节炎的临床疗效。方法:将172例类风湿关节炎患者,按照随机数字表法分为观察组和对照组,每组各86例,对照组口服阿司匹林,同时外用复方雷公藤;观察组给予宣痹达经汤内服,五虎散外敷。结果:观察组有效率为91.9%,对照组有效率为79.1%,两组有效率比较,差异有统计学意义(P<0.05);两组患者治疗前关节功能无明显统计学差异,治疗后其关节肿胀数、肿胀分级、疼痛数及疼痛分级均有所下降,观察组下降程度较对照组更为明显(P<0.05);观察组不良反应发生率为15.1%,对照组不良反应发生率为20.9%,两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论:宣痹达经汤合五虎散外敷可补益肝肾、活血通络,起到宣痹止痛之效,可有效改善类风湿关节炎患者关节肿胀、疼痛及活动障碍等症状,且无明显不良反应,疗效确切,安全性高。

Objective：To observe the clinical efficacy of Chinese medicine internal and external treatment for rheumatoid arthritis. Methods：172 cases with rheumatoid arthritis were divided into observation group and control group according to random number table method,86 cases in each group. The control group was given oral aspirin combined with external use of compound Tripterygium Wilfordii. The observation group was given Xuanbi Dajing soup combined with applyment of Wuhusan. Observe the therapeutic effect and adverse reaction. Results ：The effective rate was 91.9% in observation group and 79.1% in control group. Compared the effective power of two groups ,the difference was statistically significant（P 〈 0.05 ）. The joint function in patients of two groups had no significant statistical difference before treatment. The joint swelling number and grade of swelling, pain and pain grading were declined after treatment. The drop degree in observation group was more obvious than that in control group （ P 〈 0.05 ）. The incidence rate of adverse reactions was 15.1% in observation group and 20.9% in control group. Compared the incidence rate of two groups,there was no statistically significant difference（P 〉 0.05 ）. Conclusion：Xuanbi Dajing soup combined with Wuhusan applyment can reinforce liver and benefit kidney, promote blood circulation to remove meridian obstruction so as to achieve analgesic effect. It can effectively improve the rheumatoid arthritis patients with symptoms such as swelling, pain and impaired activity with no obvious adverse reaction, curative effect and high safety.