润兴牙龈炎冲洗器联合洁悠神在鼻咽癌放射性口腔黏膜炎中的应用

Application of Runxin gingival flusher and Jiyoushen in nasopharyngeal carcinoma with acute oral mucositis

目的探讨润兴牙龈炎冲洗器和洁悠神用于鼻咽癌放射性口腔黏膜炎的疗效，并分析其影响因素。方法将92例鼻咽癌患者随机分为研究组与对照组各46例，研究组采用润兴牙龈炎冲洗器和洁悠神长效抗菌材料进行13腔处理，对照组行常规口腔护理。结果研究组40例完成了2个周期的化疗，对照组26例完成了2个周期的化疗（X2=10．51，P=0．001）。研究组3例患者因口腔黏膜反应而延迟治疗，对照组共有13例患者延迟了至少3d以上（x2=7．57，P=0．006）。研究组40例为Ⅰ～Ⅱ级口腔黏膜反应，6例出现Ⅲ级口腔黏膜反应；对照组23例Ⅰ～Ⅱ级口腔黏膜反应，23例Ⅲ～Ⅳ级口腔黏膜反应。两组Ⅱ～Ⅳ级口腔黏膜反应，差异有统计学意义（X2=14．06，P〈0．01）。除了治疗方式，Logistic回归分析发现抽烟和男性患者与严重口腔黏膜炎发生相关。结论润兴牙龈炎冲洗器和洁悠神联合使用能明显减少Ⅱ～Ⅳ级口腔黏膜反应，并能保证治疗的顺利进行。除此之外，抽烟与严重口腔黏膜炎发生相关。

Objective To study the efficacy of Runxin gingival flusher and Jiyoushen on nasopharyngeal carcinoma with acute oral mucositis, and analyze its influencing factors. Methods Totals of 92 nasopharyngeal carcinoma patients were randomly divided into study group（ n = 46 ） and control group（ n = 46 ）. The patients of study group were treated with Runxin gingival flusher and Jiyoushen during radiation days, while control group received routine oral nursing. Results In study group, 40 patients completed two cycles chemotherapy , while that of 26 patients in control group, and the difference was statistically significant （X2 = 10.51 ,P = 0.001 ）. Patients prolonged at least 3 days in study group significantly less than that in control group for acute oral mucositis related to chemotherapy （3 vs 13, X2 = 7.57, P = 0.006）. In study group, 40 patients with I - II acute oral mucositis and 6 cases with Ill acute oral mucositis were found, while 23 cases with I - II acute oral mucositis and 23 cases with III - IV acute oral mucositis in control group, and the difference was statistically significant （ X2 = 14.06, P 〈 0.01 ）. Logistic regression analysis found that smoking and male patients related with severe oral mucositis. Conclusions Runxin gingival flusher and Jiyoushen combined for nasopharyngeal carcinoma patients could significantly reduce the incidence of II - IV acute oral mucositis, and ensure smoothing of the treatment plans. Smoking related with severe oral mucositis.