万年蒿细粉与水煎剂的急性毒性

Acute toxicity of fine powder and water apozem of the Artemisia sacrorum Ledeb for mice

[目的]评价万年蒿细粉及水煎剂对小鼠的急性毒性．[方法]采用最大给药量法测定万年蒿细粉的最大给药量；采用改良寇氏法测定万年蒿水煎剂的LDso．[结果]小鼠对万年蒿细粉的最大给药量为生药15g／kg，相当于人日常用药的60倍；万年蒿水煎剂的小鼠急性经口LD50为104．40g／kg，95％可信限为95．46～114．18g／kg．[结论]在本实验条件下，万年蒿细粉无明显急性毒性反应；万年蒿水煎剂为实际无毒级．

OBJECTIVE To study the acute toxicity of fine powder and water apozem of the Artemisia sacrorum Ledeb （A. sacrorum） for mice. METHODS The fine powder of A. sacrorum was administered with maximum administration dosage, and median lethal dose （LDs0） of the water apozem of A. sacrorum in mice was determined by modified Kaber method. RESULTS The maximum administration dosage was 15 g/kg of fine powder of A. sacrorum in mice, that was equivalent to man＇s daily administration dosage by 60 times, and LD50 of water apozem of A. sacrorum was 104. 40 g/kg, 95% of confidence interval was 95.46 - 114. 18 g/kg. CONCLUSION The gastric administration with fine powder of A. sacrorum has no acute toxicity reaction for mice, and the water apozem of A. sacrorum has no realistically toxic grade in this experiment.