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miRNA-210在恶性肿瘤中的研究进展 被引量:2

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摘要 恶性肿瘤是目前导致人类死亡的主要病因,据统计每年有数以万计的人死于癌症。临床上尽管可以通过早发现、早诊断、改进治疗方法及加强护理等传统手段提高肿瘤患者的生存率,降低死亡率,但目前缺乏敏感而特异的早期诊断标志物,虽然病理检查的准确率很高,但该法属有创检查不适用于普查和筛查。传统治疗手段创伤大,副作用明显,导致患者预后较差。况且人们对肿瘤的发病机制仍然不明确,所以进一步了解肿瘤发病的分子生物学特性或许可以找到诊断和治疗肿瘤更好的方法和途径。
作者 方茜 郝岗平
出处 《泰山医学院学报》 CAS 2013年第5期396-400,共5页 Journal of Taishan Medical College
基金 国家自然科学基金资助(81173489)
关键词 乏氧 miRNA-210 肿瘤
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  • 1Cho WC,Chow AS,Au JS.Restoration of tumour suppressor hsa-miR- 145 inhibits cancer cell growth in lung adenocarcinoma patients with epidermal growth factor receptor mutation. European Journal of Cancer . 2009
  • 2Hidalgo M.Pancreatic cancer. The New England Journal of Medicine . 2010
  • 3Shuangni Yu,Zhaohui Lu,Changzheng Liu,et al.miRNA-96 Suppresses KRAS and Functions as a Tumor Suppressor Gene in Pancreatic Cancer.. Cancer Research . 2010
  • 4Hingorani SR,Wang L,Multani AS,Combs C,Deramaudt TB,Hruban RH,Rustgi AK,Chang S,Tuveson DA.Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell . 2005
  • 5Bardeesy N,Aguirre AJ,Chu GC,Cheng KH,Lopez LV,Hezel AF,Feng B,Brennan C,Weissleder R,Mahmood U, et al.Both p16 (Ink4a) and the p19 (Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse. Proceedings of the National Academy of Sciences of the United States of America . 2006
  • 6Schickel R,Park SM,Murmann AE,Peter ME.miR-200c regulates induction of apoptosis through CD95by targeting FAP-1. Molecular Cell . 2010
  • 7Giannakakis A,Sandaltzopoulos R,Greshock J,Liang S,Huang J,Hasegawa K,Li C,O‘Brien-Jenkins A,Katsaros D,Weber BL,Simon C,Coukos G,Zhang L.miR-210links hypoxia with cell cycle regulation and is deleted in human epithelial ovarian cancer. Cancer Biology and Therapy . 2008
  • 8TMBL Z,SZABP M,MOLNR V,et al.Integrative molec-ular bioinformatics study of human adrenocortical tumors:microR-NA,tissue-specific target prediction,and pathway analysis. Endocrine Related Cancer . 2009
  • 9Imke Satzger,Anika Mattern,Uta Kuettler,Dirk Weinspach, et al.MicroRNA-15b represents an independent prognostic parameter and is correlated with tumor cell proliferation and apoptosis in malignant melanoma. International Journal of Cancer . 2010
  • 10E Miko,Z Czimmerer,E Csanky,G Boros,J Buslig,B Dezso,B Scholtz.Differentially expressed microRNAs in small cell lung cancer. Experimental Lung Research . 2009

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