p73a和血管内皮生长因子-C在子宫内膜癌发生发展过程中的作用

Role of p73a and VEGF-C in the development and progression of endometrial carcinoma

目的探讨p73a和血管内皮生长因子-C(VEGF-C)在子宫内膜癌发生发展过程中的作用。方法采用免疫组织化学S-P法检测正常子宫、增生期子宫、子宫内膜癌组织中p73a、VEGF-C蛋白表达。结果子宫内膜癌组织中p73a、VEGF-C表达阳性率明显高于正常、增生过长、不典型增生子宫内膜(P<0.01或0.05)。p73a表达与临床分期无关(P>0.05),而VEGF-C表达与临床分期、肌层浸润有关(P<0.01或0.05)。子宫内膜癌组织中p73a与VEGF-C表达呈显著正相关(P<0.05)。结论 p73a、VEGF-C在子宫内膜癌发生、发展中起重要作用,VEGF-C可作为预后判断指标。

Objective To investigate the role of p73α and VEGF-C in the development and progression of endometrial carcinoma （EC）. Methods Expression ofp73a and VEGF-C protein in normal and proliferative endometria and EC was detected by S-P immunohistochemical method. Results Expression rates of p73α and VEGF-C were significantly higher in EC than those in normal, proliferative and atypical endometria （P〈0.01 or 0.05）. Expression of p73α was not associated with clinical staging （P〉0.05）, while Expression of VEGF-C was related to clinical staging muscular invasion （P〈0.01 or 0.05）. There was a positive correlation between p73α and VEGF-C expression in EC （P〈0.05）. Conclusion VEGF-C and p73α may play an important role in the development and progression of EC, and VEGF-C could be a prognostic marker for EC.