骨伤科住院患者MRSE和MRSA感染连续五年耐药分析

Drug-resistant analysis of MRSE and MRSA in orthopedic inpatient to for five consecutive years

目的了解本院骨伤科住院患者手术切口感染耐甲氧西林表皮葡萄球菌(MRSE),耐甲氧西林金黄色葡萄球菌(MRSA)的耐药情况,为临床合理使用抗菌药物提供依据。方法采用ATB-Press全自动微生物分析仪进行鉴定和药敏试验,头孢西丁纸片扩散法进行MRSE、MRSA菌株鉴定。结果 5年中,共检出652例球菌,检出率最高的是表皮葡萄球菌,占42.05%,其次是溶血葡萄球菌,占13.46%,金黄色葡萄球菌,占13.28%;而5年来,MRSE、MRSA对于大多数的抗菌药物的耐药率都呈不断上升的趋势,其中对万古霉素、替考拉宁都是敏感。结论所检出球菌中,表皮葡萄球菌的检出率最高,呈不断上升趋势;临床应加强MRSE、MRSA的监测,根据药敏结果合理用药,防止耐药菌的播散。

Objective To understand the drug resistance in hospitalized patients with operation incision infected with MRSE or MRSA to provide basis for clinical rational use of antibiotics.Methods Identification and drug sensitivity test were did by ATB-Press automatic microorganism analyzer,the cefoxitin disk diffusion method for indentification of the MRSE and MRSA was used.Results In five years,652 patients with gonorrhoeae were detected,the highest detection rate was Staphylococcus epidermidis which accounted for 42.05%,followed by Staphylococcus haemolyticus which accounted for 13.46%,Staphylococcus aureus accounted for 13.28%.During the five years,MRSE and MRSA showed a rising trend of most antibiotic-resistance,while still sensitive to vancomycin and teicoplanin.Conclusion The detection rates of Staphylococci and Staphyloccus aureus were the highest,and with a rising trend.It should be a wake-up call for clinical department,where the monitoring of MRSE and MRSA should be strengthened,and rational use of drug according to the results of drug sensitivity is suggested to prevent the spread of resistant bacteria.