电刺激大鼠前庭神经内侧核对胃运动、呼吸运动和心率的影响

STUDY ON THE EFFECTS OF ELECTRIC STIMULATION OF VESTIBULAR NUCLEUS ON GASTRIC MOTILITY, RESPIRATORY MOVEMENTS AND HEART RATE IN RATS

利用Wistar雄性大鼠，研究了前庭神经内侧核的兴奋对胃运动、呼吸运动及心率的影响．利用核团电刺激方法对大鼠前庭神经内侧核进行刺激，测定该刺激对大鼠胃运动、呼吸频率及心率形成的影响．刺激参数为：波宽0．3ms，强度0．2mA，频率30Hz；刺激位点为前囟后11．04mm，中线旁开1．2mm，露骨表面下7．5mm．电刺激中和刺激后的胃运动，与刺激前相比差异无统计学意义（P〉0．05）；在刺激过程中，呼吸频率和心率都有一定程度的增加，差异有统计学意义．心率在第一次刺激和第二次刺激过程中，与刺激前相比分别增加了3．5％（P〈0．05）和2．9％（P〈0．05）．呼吸频率在第一次刺激和第二次刺激过程中，刺激前相比分别增加了8．9％（P〈0．05）和8．2％（P〈0．05）．大鼠前庭内侧核兴奋引起心率和呼吸运动的显著改变，但不引起胃运动的变化．原因可能与大鼠无呕吐现象有关，有待继续研究．

We investigated the effects of electric stimulating vestibular nucleus on gastric motility, respiratory movements and heart rate in male Wistar rats. We investigated the effects on gastric motility, respiratory movements and heart rate by stimulating vestibular nucleus of Wistar rats. The Electrical stimulation parameters were square waves with width 0.3 ms, intensity 0.2 mA, frequency 30 Hz. The coordinate of stimulation sites was 11.04 mm posterior to the Bregma, 1.2 mm lateral to the midline, 7.5 mm beneath the skull surface. The gastric motility during and after stimulation has no changes compared to that before stimulation. During this stimulus, the heart rate and respiratory frequency significantly increased. The heart rate during the first stimulation and the second stimulation were respectively increased by 3.5% （ P 〈 0.01 ） and 2.9% （ P 〈 0.05 ） compared to that before stimulation. The respiratory frequency during the first stimulation and the second stimulation were respectively increased by 8.9% （ P 〈 0.05 ） and 8.2% （ P 〈 0.05 ） compared to that before stimulation. The research indicates that excitation of medial vestibular nucleus in rats causes prominent change of heart rate and respiratory frequency, but it causes no change of gastric motility. The reason may be that there is no vomiting center in rats, which needs for further study.