正交设计法催化氢化制备2,4,5-三氨基-6-羟基嘧啶

Preparation of 6-Hydro-2,4,5-triaminopyrimidine by Using Orthogonal Design Test

以Pd/C为催化剂直接催化氢化 2 ,4 二氨基 6 羟基 5 亚硝基嘧啶制备 2 ,4,5 三氨基 6 羟基嘧啶 ,采用正交设计方法考察了碱的浓度、溶剂、催化剂用量、温度、反应时间等对反应的影响 ,收率在 90

Hydroxy 2,4,5 triaminopyrimidine was prepared by the hydrogenation of 2,4 diamino 6 hydroxy 5 nitrosopyrimidine over Pd/C catalyst, the synthetic conditions were optimized by orthogonal design, the best result, over 90% yield was afforded.