不同提取方法的中药解酒剂防治酒精中毒的药效学研究

Pharmacodynamics study of Chinese traditional dealcoholic medicine prepared from different extraction methods applied to the prevention and cure of alcoholism

通过观察小鼠翻正反射消失情况 ,测定鼠血中乙醇浓度和超氧化物歧化酶 (SOD)酶活 ,考察了中药解酒剂的不同制备方法对小鼠急性酒精中毒的防治功效 .研究结果表明 ,采用 6 5%乙醇醇提 3次的工艺所制备的中药解酒剂具有最优的解酒防醉功效 ,在同样的建议摄入量条件下 ,对小鼠急性酒精中毒的防治功效优于目前国内外同类产品 ,经t检验与对照组比较 ,显著性p<0 .0 1.

The effects of Chinese traditional dealcoholic medicine prepared from different extraction methods on the acute alcoholism prevention and cure were studied by observing the rats' reflect-disappear condition and determining ethanol concentration and SOD enzyme activity in rat blood. The results showed that the medicine prepared by the technology of extracting three times from 65% alcohol had the best dealcoholic effects. Under the conditions of intaking the same recommended dose, the effects of these Chinese traditional dealcoholic medicines on the acute alcoholism prevention and cure were much better than those of similar products available and the “t detection” showed the significance p0.01.