不同麻醉药物对老年患者全麻术后认知功能的影响比较

Comparison of different anesthesia drug effects on cognitive function in elderly patients after general anesthesia

目的本文主要比较不同麻醉药物对老年患者全麻术后认知功能的影响。方法收集2011年06月到2012年06月本医院收治的100例进行全麻手术的老年患者临床资料,随机分为观察组与对照组,每组各50例。观察组患者采取瑞芬太尼麻醉药,给予对照组芬太尼麻醉药,最后分析两组患者的手术、睁眼、语言陈述等方面所需要的时间。对比两组术后1 h、6 h、12 h、24 h的MMSE评分。结果观察组的睁眼时间、语言陈述时间均短于对照组,两组对比差异具有统计学意义(P<0.05)。观察组术后1 h、6 h、12 h、24 h的MMSE评分均胜于对照组,两组差异具有统计学意义(P<0.05)。结论瑞芬太尼全麻老年患者所需要的苏醒与恢复时间比较短,认知功能恢复相对比较快,促进患者恢复,值得临床推广。

Objective This paper mainly compare the effects of different anesthetic drugs on cognitive function in elderly patients after general anesthesia. Methods From June 2011 to June 2012 the hospital＇ s 100 cases under general anesthesia operation in elderly patients with clinical data, were randomly divided into observation group and control group, each group of 50 cases. Patients in the observation group took remffentanil anesthesia, the control group received fentanyl anesthesia, finally analysis to two groups of patients with opera- tion, open eyes, language and other aspects of the time. Between the two groups were 1 h, 6 h, 12 h, 24 h, MMSE score. Results The group of opening time, language statement time was shorter than the control group, the differences between two group significantly, with statistical significance （ P 〈 0. 05 ）. The patients in the ob- servation group 1 h, 6 h, 12 h, 24 h and MMSE scores were better than the control group, the two groups dif- fered significantly, with statistical significance （P 〈 0. 05 ）. Conclusion Remifentanil in elderly patients need to compare with short recovery time, cognitive function recovered relatively quickly, promote the recovery of pa- tients, is worthy of clinical application.