伽玛刀治疗大脑镰旁脑膜瘤98例临床分析

Clinical analysis of gamma knife treatment for 98 cases with cerebral falx meningiomas

目的研究伽玛刀治疗肿瘤最大径<30 mm的大脑镰旁脑膜瘤的效果。方法对2002年8月～2010年7月肿瘤最大径<30 mm的98例大脑镰旁脑膜瘤患者进行伽玛刀治疗。肿瘤最大径<10 mm 51例、10～<20 mm 36例、20～<30 mm 11例,伽玛刀治疗处方剂量为26～32 Gy,50%的等剂量线包绕。结果随访98例,随访23～81个月(平均52个月)。肿瘤消失37例,肿瘤缩小41例,肿瘤无变化14例,肿瘤继续增大6例。肿瘤生长控制率为93.9%(92/98),其中肿瘤最大径<20 mm的肿瘤控制率达96.6%(84/87)。出现肿瘤周围脑水肿反应17例。结论伽玛刀治疗大脑镰旁脑膜瘤安全有效,肿瘤最大径<20 mm为最佳。

Objective To study the effect of gamma knife treatment for 98 cases with cerebral falx meningiomas esti- mate of the tumour maximum diameter 〈30 mm. Methods 98 patients with cerebral falx meningiomas of the tumour maximum diameter 〈30 mm were treated with Gamma Knife from August 2002 to July 2010.51 cases with tumour di- ameter 〈10 mm,36 cases with tumour diameter 10-〈20 ram,11 cases with tumour diameter 20-〈30 mm,the prescribed doses of the treatments were 26-32 Gy,with 50% isodose curves. Results 98 patients were followed up for 23 to 81 months （on average of 52 months）.The tumour disappeared in 37 cases,shrunk in 41 cases,stayed in the same in 14 cases,recurrent in 6 cases.The control rate of tumour growth was 93.9% （92/98）,the control rate of tumour maximum diameter 〈20 mm was 96.6% （84/87）.Peritumoral vasogenic brain edema in 17 cases. Conclusion Treatment of cere- bral falx meningiomas with gamma knife is effective and safe methods.The tumour maximum diameter 〈20 mm should be as most suitable.