百草枯中毒患者纤溶指标和细胞因子的变化

Changes of fibrinolytic index and cytokines in patients with paraquat poisoning

目的探讨百草枯中毒患者纤溶指标和白细胞介素-6(IL-6)、IL-8的变化及相关性。方法将49例急性百草枯中毒患者分成轻、中、重度3组,20例健康体检者作为对照组。用CA-7000全自动凝血分析仪检测血中D-二聚体和纤维蛋白(原)降解产物(FDP)水平,采用ELISA法检测血IL-6、IL-8水平。结果轻度组各项指标与正常对照组比较,差异无统计学意义(P>0.05),中、重度组各项指标较轻度组明显升高(P<0.01),且重度组各指标明显高于中度组(P<0.01)。结论百草枯中毒引起细胞因子紊乱并影响了患者的纤溶功能,而细胞因子、纤溶功能改变在器官损伤过程中可能起重要作用。

Objective to investigate changes and correlation of fibrinolytic function and cytokines in patients with paraquat poisoning. Methods 49 patients wit l？ acute paraquat poisoning were divided into the slight poisoning group, the moderate poisoning group and the server poisoning group.20 healthy subjects were selected as the normal control group. D-dimer and fibrinogen degradation products （FDP） were determined by CA-7000 automatic coagulation ana- lyzer.Interleukin-6（IL-6） and interleukin-8（IL-8） were measured with ELISA method. Results The levels of all indi- cators in the slight poisoning group had no significantly difference compared with the normal control group （P〉0.05）. The levels of them in the moderate and sever poisoning group were higher than them of the slight poisoning group （P〈 0.01）,while the levels of them in the sever poisoning group Were higher than them of the moderate group （P〈0.01）. Conclusion Paraquat poisoning makes cytokines disorder and affects on the fibrinolytic function of patients,while the changes of cytokines and fibrinolytic function may participate the damage of organ.