肝脏局灶性结节性增生1例

One case of focal nodular hyperplasia in the liver

本文依据本院接诊的病例以及国内外相关文献,探讨肝脏局灶性结节性增生(FNH)的临床诊断和治疗。FNH的病因及发病机制至今尚无定论,但相关研究认为可能与激素类药物刺激、口服避孕药等有关。该疾病多见于30～50岁的女性,女性发病率是男性的2倍,80%的病例没有特异性的临床表现,影像学检查和经皮肝穿刺活检是目前确诊该病的主要手段。就治疗而言,手术切除被认为是治疗FNH的最优选择,既可以去除病灶,又能明确诊断,不过需要严格掌握手术适应证。另外,没有必要立即进行手术治疗者,需定期随访。

To explore the clinical diagnosis and treatment of focal nodular hyperplasia （FNH） in the liver based on the case admitted into our hospital and relevant literatures both at home and abroad. The results showed that there was still no definite conclusion about the etiology and pathogenesis of FNH, but some researches indicated that it might be related with stimulation of hormone drugs and oral contraceptives, etc. The disease was more common in women aged 30 to 50 years old and the incidence in female was double compared with that in the male. 80% cases didn＇t present with any specific clinical manifestations. The principal means to definitely diagnose the disease currently were image examination and percutaneous liver biopsy. In the aspect of treatment, surgical resection was considered as the optimal selection to treat FNH for both removing focus and confirming diagnosis, but the indications for surgery should be strictly mastered. Besides, for patients with FNH, if it was not necessary to perform surgery right away, then the regular follow-up visit was required.