代谢综合征大鼠肝肾功能和肾动脉形态结构的变化

Changes of liver and kidney function and morphology of the renal artery of the metabolic syndrome rats

目的 探讨代谢综合征大鼠肝肾功能的变化和肾动脉形态结构的改变.方法 分别用普通及高果糖饲料喂养大鼠（60只）10周,然后取血及解剖观察,了解大鼠肝肾功能和肾动脉形态结构的变化.结果 对照组大鼠和MS组大鼠血清ALT、AST、UA、BUN、CR浓度随着喂养时间延长均有上升趋势,但MS组大鼠上升速度明显快于对照组大鼠,表现出肝肾功能损害,与临床上MS病例类似；与对照组相比较,MS组大鼠肾动脉内膜呈不均一增厚、结构紊乱,中膜平滑肌细胞向内膜增生,内弹力膜有不同程度破坏、断裂,中膜层弹力纤维增厚,结构紊乱,平滑肌细胞增生明显,内中膜明显增厚,出现了MS病例所呈现的病理改变.结论 代谢综合征大鼠有轻度的肝肾功能损害,肾动脉内中膜有异常改变.

Objective To investigate the changes of liver and kidney function and morphology of the renal artery of the metabolic syndrome （MS） rats. Methods The rats were respectively fed with ordinary or high-fructose diet for 10 weeks, and then took the blood and anatomical observation, to explore the changes of liver and kidney function and morphology of the renal artery of the rats. Results The serum levels of ALT, AST, UA, BUN, CR in the control group and MS group were gradually increased with the feeding time. But those in MS rats were significantly increased than the control rats. MS rats showed dysfunction of liver and kidney, which similar to the clinical MS cases. Compared with the control group, the renal artery of MS rats had the same pathological changes as MS cases, presented with intima uneven thickening and structural disorder, medial smooth muscle cells hyperplasia to intimal, the internal elastic membrane with different degrees of damage and fracture, the film elastic fibers thickening and structural disorder,smooth muscle cell proliferation apparently,medial obvious thickening. Conclusion MS rats have mild dysfunction of liver and kidney and abnormal changes in intima and tunica media of renal artery.