布地奈德联合硫酸镁对支气管哮喘急性期患儿血清免疫球蛋白E和白细胞介素-17的影响

The influence of budesonide plus magnesium sulfate on serum IgE and IL-17 in children with acute bronchial asthma

目的 观察布地奈德联合硫酸镁对支气管哮喘急性期患儿血清免疫球蛋白E（IgE）和白细胞介素-17 （IL-17）的影响.方法 86例支气管哮喘急性发作患儿采用随机数字表法分为两组,观察组43例,对照组43例,对照组采用常规治疗加用静脉激素,观察组采用常规治疗加用雾化吸入布地奈德联合硫酸镁治疗,共治疗7d.测定患者血清IgE和IL-17.结果 治疗后观察组总有效率为97.7％,高于对照组的88.4％（x2=5.24,P＜0.01）.两组治疗后患者血清IgE和IL-17均有明显降低（t=21.7119、13.0190、11.2647、7.1588,均P＜0.01）,与对照组治疗后比较,观察组降低更明显（t=13.8141、5.1214,均P＜0.05）.结论 布地奈德联合硫酸镁可以明显减少支气管哮喘急性发作患儿血清IgE和IL-17表达.

Objective To observe the effect of budesonide plus magnesium sulfate on serum IgE and interleukin-17 （IL-17） in children with acute bronchial asthma. Methods 86 children with acute bronchial asthma were randomly divided into the observation group（ n =43 cases） and the control group（ n =43 cases）. The children in control group were treated through the conventional treatment plus intraveneous hormone, and the children in the observation group were treated through the conventional treatment plus budesonide and magnesium sulfate. They were treated for 7 days. Serum IgE and IL-17 were detected before and after treatment. Results The total effective rate of the ob- servation group was 97.7%, which was significantly higher than 88.4% of the control group （ X^2 = 5.24,P 〈 0.05 ）. Serum IgE and IL-17 levels were decreased after treatment in both two groups （ t = 21. 7119,13. 0190, 11. 2647, 7. 1588, P 〈 0.01 ）, and compared with the control group, those in the observation group were significantly lower （t = 13. 8141,5. 1214 ,all P 〈 0.05 ）. Conclusion Budesonide plus magnesium sulfate can significantly decrease serum lgE and IL-17 in children with acute bronchial asthma.