氟哌噻吨-美利曲辛对老年人冠脉介入术后焦虑抑郁的疗效观察

Observation of the effect of Deanxit in the treatment of elderly patients with anxiety and depression after PCI

目的 观察氟哌噻吨-美利曲辛片（黛力新）干预老年冠心病冠脉介入治疗（PCI）伴焦虑抑郁患者的临床疗效.方法 对70岁以上的老年冠心病患者PCI术后3d内进行汉密尔顿焦虑量表（HAMA）、汉密尔顿抑郁量表（HAMD）心理测试,筛选出伴焦虑抑郁的患者80例,随机数字表法等分为黛力新组和对照组,黛力新组在PCI术后第3天开始在常规内科药物治疗基础上给予每天早晨、中午各1片黛力新口服；对照组在PCI术后给予常规内科治疗及安慰剂.12周后分别对两组的HAMA、HAMD评分进行比较.结果 黛力新组HAMA评分[（10.2±5.7）分比（17.8±5.5）分,P=0.012]和HAMD评分[（11.8±6.2）分比（18.3±4.3）分,P=0.020]均低于对照组.结论 氟哌噻吨-美利曲辛可明显改善老年冠心病PCI术后患者的焦虑抑郁症状.

Objective To investigate the effects of Deanxit on elderly patients with anxiety and depression symptoms after percutaneous coronary intervention （PCI）. Methods The Hamilton Anxiety Scale （HAMA） and Hamilton Depression Scale（HAMD） were used to evaluate the anxiety and depression symptoms in elderly patients （more than 70 years old） with coronary heart disease after PCI. Thus, 80 patients with anxiety and depression after PCI were singled out, they were randomly divided into Deanxit group （ n = 40,2 Deanxit tablets daily） and control group（ n = 40, conventional therapy）. HAMA and HAMD scores were performed after treatment for 12 weeks. Results HAMA and HAMD scores of the Deanxit group were （ 10.2 ± 5.7 ） points, （ 11.8±6.2 ） points, which were significantly lower than （17.8±5. 5）points, （18. 3±4. 3） points in the control group （P =0. 012,P =0.020）. Condusion Deanxit can significantly improve the anxiety and depression symptoms in elderly patients after PCI.