不同剂量砷对大鼠大脑皮层乙酰胆碱脂酶活性的影响

Effect of difference dose arsenite on AChE of cerebral cortex in rat

目的:探讨不同剂量砷对大鼠大脑皮层乙酰胆碱脂酶(AChE)的影响。方法:以剂量递增法建立染砷大鼠动物模型。12周后,测定不同剂量砷对大鼠大脑皮层乙酰胆碱脂酶(AChE)。结果:不同剂量染砷组间大鼠大脑皮层乙酰胆碱脂酶(AChE)活性有显著性差别(P<0.05),随剂增加AChE值降低(P<0.05),呈剂量—效应关系。低剂量组与正常对照组相比,乙酰胆碱脂酶活性无显著性差别(P>0.05)。结论:随染砷剂量增加,大鼠大脑皮层AChE活性降低,呈剂量—效应关系。

Objective： To study the effect of difference dose Arsenite on acetylcholinease of cerebral cortex. Methord： Animal model were created by means of increasing dose . After 12 week, the activity of AChE in cerebral cortex of four group rats were measured. Results： AChE activity of cerebral cortex in rat was significantly different in the differert dose groups （P 〈 0.05 ）. With the rise of dose, AchE level in cerebral cortex was markedly lower（ P〈 0.05 ）, and was in a dose- effect manner. AChE activity was not significantly different between low- does and high- dose group（ P 〉 0.05 ） . Conclusion： Level of AChE of cerebral cortex could be affected by Arsenity. the change was in a dose- effect manner.